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- 저자 : Nergiz Ekmen (검색결과 1 건)
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Evaluation of Non-invasive Fibrosis Markers in Predicting Esophageal Variceal Bleeding
Sami Cifci,Nergiz Ekmen 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6
Background/Aims: Esophageal variceal bleeding (EVB) is an important cause of mortality and morbidity in liver cirrhosis. In thisstudy, we aimed to predict the possibility of EVB in patients with cirrhosis using a non-invasive score. Methods: A total of 359 patients with cirrhosis were divided into two groups based on the presence or absence of EVB. Child-Turcotte-Pugh (CTP) score, a model for end-stage liver disease, aspartate aminotransferase to alanine aminotransferase ratio,aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4-index (FIB-4), aspartate aminotransferase to alanineaminotransferase ratio/platelet ratio index (AARPRI), and S-index were measured for all participants. Receiver operatingcharacteristic curves were obtained for all parameters, and the optimal cut-off value was determined in predicting EVB. Results: In patients with EVB, the number of platelets (PLT) were low (p<0.001) and APRI, AARPRI, FIB-4, and S-index weresignificantly higher than those in patients without EBV. APRI, AARPRI, FIB-4, PLT, and S-index were statistically significantpredictors of EVB (p<0.05). Conclusions: FIB-4 and AARPRI, which are non-invasive markers of fibrosis, can be used to predict EVB. In addition, the 66.5 109/Lcut-off value for PLT is important for EVB.
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