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Transcutaneous medial plantar nerve stimulation in women with idiopathic overactive bladder
Necmettin Yildiz,Rafet Sonmez 대한비뇨의학회 2023 Investigative and Clinical Urology Vol.64 No.4
Purpose: To define transcutaneous medial plantar nerve stimulation (T-MPNS) as a new neuromodulation method and assess the efficacy of T-MPNS on quality of life (QoL) and clinical parameters associated with incontinence in women with idiopathic overactive bladder (OAB). Materials and Methods: Twenty-one women were included in this study. All women received T-MPNS. Two self-adhesive surface electrodes were positioned with the negative electrode near the metatarsal-phalangeal joint of the great toe on the medial aspect of the foot and the positive electrode 2 cm inferior-posterior of the medial malleolus (in front of the medio-malleolar-calcaneal axis). T-MPNS was performed 2 days a week, 30 minutes a day, for a total of 12 sessions for 6 weeks. Women were evaluated for incontinence severity (24-h pad test), 3-day voiding diary, symptom severity (Overactive Bladder Questionnaire [OAB-V8]), QoL (Quality of Life-Incontinence Impact Questionnaire [IIQ-7]), positive response and cure-improvement rates, and treatment satisfaction at baseline and at the 6th week. Results: Statistically significant improvement was found in the severity of incontinence, frequency of voiding, incontinence episodes, nocturia, number of pads, symptom severity, and QoL parameters at the 6th week compared with baseline. Treatment satisfaction, treatment success, and cure or improvement rates were found to be high at the 6th week. Conclusions: T-MPNS was first described in the literature as a new neuromodulation method. We conclude that T-MPNS is effective on both clinical parameters and QoL associated with incontinence in women with idiopathic OAB. Randomized controlled multicenter studies are needed to validate the effectiveness of T-MPNS.
Effect of Probiotics on the Treatment of Children with Atopic Dermatitis
( Yavuz Yesilova ),( Omer Calka ),( Necmettin Akdeniz ),( Mustafa Berktas ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.2
Background: Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic dermatitis. Objective: In this double-blind, randomized, placebo-controlled study, a combination of Bifidobacterium bifidum, Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus salivarius strains were evaluated in the treatment of atopic dermatitis in pediatric patients. Methods: Forty pediatric patients (23 males and 17 females) aged 1∼13 years were enrolled. One eligible individual who was approached declined to participate. The probiotic group was administered a probiotic complex containing B. bifidum, L. acidophilus, L. casei, and L. salivarius for 8 weeks. The placebo group, on the other hand, was administered skim milk powder and dextrose. All of the parameters including serum cytokines, eosinophil cationic protein), SCORing Atopic Dermatitis (SCORAD) index, and total serum immunoglobulin E (IgE) were measured in both the probiotic group and the placebo group at the end of 8 weeks. Results: Probiotic intervention in pediatric atopic dermatitis patients effectively reduced the SCORAD index and serum cytokines interleukin (IL)-5, IL-6, interferon (IFN)-γ, and total serum IgE levels, but did not reduce levels of serum cytokines IL-2, IL-4, IL-10, ECP, or tumor necrosis factor-α (TNF-α) compared to the placebo group. Conclusion: Our study found probiotics to be effective in reducing atopic dermatitis patients` SCORAD index, serum IL-5, IL-6, IFN-γ, and total serum IgE levels but not effective in reducing serum IL-2, IL-4, IL-10, ECP, or TNF-α levels. (Ann Dermatol 24(2) 189∼193, 2012)
Determination of Thermo-Electrical Properties in Sn Based Alloys
Sezen Aksöz,Yavuz Ocak,Kâzlm Keslioslu,Necmettin Mara ll 대한금속·재료학회 2010 METALS AND MATERIALS International Vol.16 No.3
The variation of thermal conductivity of solid phase versus temperature for Sn-21 wt.% Bi, Sn-25 wt.% In and Sn-35 wt.% In-26 wt.% Bi alloys were measured with a radial heat flow apparatus. From the graphs of thermal conductivity versus temperature, the thermal conductivity of the solid phases at their melting temperatures and the thermal temperature coefficients for the same alloys were obtained. The ratios of thermal conductivity of liquid phase to solid phase for the same materials were measured with a Bridgman type directional solidification apparatus. The variations of electrical conductivity of solid phases versus temperature for the same alloys were determined from the Wiedemann-Franz law by using the measured values of thermal conductivity. From the graphs of electrical conductivity versus temperature, the electrical temperature coefficients for the same alloys were also determined. According to present experimental results it can be concluded that the thermal and electrical conductivity of Sn based alloys depend on the thermal and electrical conductivity of the alloying elements. If the thermal and electrical conductivity of the alloying elements are lower than the thermal conductivity of Sn, the thermal conductivity of Sn based alloys decreases, whereas, otherwise,it increases.
Oguz Dogan,Fatih Karpat,Celalettin Yuce,Necmettin Kaya,Nurettin Yavuz,Hasan Sen 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.6
This paper presents a methodology for re-designing a failed tractor transmission component subjected to cyclic loading. Unlike other vehicles, tractors cope with tough working conditions. Thus, it is necessary to re-design components by using modern optimization techniques. To extend their service life, we present a design methodology for a failed tractor clutch power take-off finger. The finger was completely re-designed using topology and shape optimization approach. Stress-life based fatigue analyses were performed. Shape optimization and response surface methodology were conducted to obtain optimum dimensions of the finger. Two design parameters were selected for the design of experiment method and 15 cases were analyzed. By using design of the experiment method, three responses were obtained: Maximum stresses, mass, and displacement depending on the selected the design parameters. After solving the optimization problem, we achieved a maximum stress and mass reduction of 14% and 6%, respectively. The stiffness was improved up to 31.6% compared to the initial design.
Experimental Determination of Interfacial Energies for Solid Sn in Equilibrium with Sn-Mg-Zn Liquid
Yemliha Altıntas,Esra Öztürk,Sezen Aksöz,Kâzım Keşlioğlu,Necmettin Maraşlı 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.2
The equilibrated grain boundary groove shapes of solid Sn in equilibrium with Sn-Mg-Zn liquid were observedfrom a quenched sample by using a radial heat flow apparatus. The Gibbs-Thomson coefficient, solid-liquidinterfacial energy and grain boundary energy of solid Sn were determined from the observed grain boundarygroove shapes. The thermal conductivity of the eutectic solid phase for Sn-8.12 at% Mg-4.97 at% Zn alloy and thethermal conductivity ratio of the liquid phase to the solid phase for Sn-8.12 at% Mg-4.97 at% Zn alloy at eutectictemperature were also measured with a radial heat flow apparatus and a Bridgman-type growth apparatus,respectively. The Gibbs-Thomson coefficient, solid-liquid interfacial energy and grain boundary energy of solidSn in equilibrium with Sn-Mg-Zn liquid were determined to be (8.3 ± 0.6)×10-8 Km, (118.5 ± 14.2)×10-3 Jm-2and (225.1 ± 29.3)×10-3 J m-2 respectively from observed grain boundary groove shapes. A comparison ofpresent results for solid Sn in the Sn-8.12 at% Mg-4.97 at% Zn alloy with the results obtained in previous worksfor similar solid Sn in equilibrium with different binary or ternary liquid was made.
Experimental Determination of Interfacial Energy for Solid Zn Solution in the Sn-Zn Eutectic System
Fatma Meydaneri,Mehtap Payveren,Buket Saatçi,Mehmet Özdemir,Necmettin Marasli 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.1
The grain boundary groove shapes for Zn solid solution in equilibrium with Sn-Zn eutectic liquid were observed with a radial heat flow apparatus. From the observed grain boundary groove shapes, the Gibbs-Thomson coefficient, the solid-liquid and the grain boundary energy for the Zn solid solution in equilibrium with Sn-Zn eutectic liquid were determined to be (2.32 ± 0.13)×10−8Km, (120.87 ± 13.29)×10−3J.m−2and (194.76± 23.37)×10−3J.m−2, respectively. The termal conductivity of the eutectic Sn- 9 wt% Zn solid solution, κS,was obtained as 74.74 W/Km by using a radial heat flow apparatus. The thermal conductivity ratio of the eutectic liquid to the eutectic solid, R = κL/κS was found to be 0.58 with a Bridgman-type directional growth apparatus. Thus, the value of the thermal conductivity of eutectic Sn- 9 wt% Zn liquid solution, κL, was obtained as 43.82 W/Km.
PPAR-Gamma Pro12Ala Polymorphism and Gastric Cancer Risk in a Turkish Population
Canbay, Emel,Kurnaz, Ozlem,Canbay, Bahar,Bugra, Dursun,Cakmakoglu, Bedia,Bulut, Turker,Yamaner, Sumer,Sokucu, Necmettin,Buyukuncu, Yilmaz,Yilmaz-Aydogan, Hulya Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Background: Peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) is a ligand dependent transcription factor involved in various processes, including carcinogenesis. We aimed to investigate any possible association of the $PPAR{\gamma}$ Pro12Ala (rs1801282) polymorphism with risk of developing gastric cancer (GC). Patients and Methods: A hospital based case control study was designed covering 50 patients with GC and 120 healthy controls. The frequencies of $PPAR{\gamma}$ Pro12Ala (rs1801282) were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results: The Ala12 allele of the $PPAR{\gamma}$ Pro12Ala G gene was associated with a 1.95 fold increased risk of GC development (p: 0.022; 95% CI: 1.58-2.40). Subgroup analyses showed that the same allele was also associated with metastasis (p: 0.000; OR:4.09; 95%CI:2.273-7.368) and differentiation (p: 0.004; OR:1.95; 95%CI:1.335-2.875) in patients with GC. Conclusion: This study suggests that the $PPAR{\gamma}$ Pro12Ala G (Ala12) allele might be associated with development, differentiation and metastatic process of GC in the Turkish population. Further studies conducted in larger study groups and in different ethnic populations will be needed to clarify the exact role of the $PPAR{\gamma}$ Pro12Ala polymorphism in GC.