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RISS 인기검색어
- 검색키워드
- 저자 : Nazar Ul Islam (검색결과 2 건)
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- 기관 내 무료
- 유료
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Ali, Gowhar,Subhan, Fazal,Islam, Nazar Ul,Ullah, Nasir,Shahid, Muhammad,Ullah, Sami,Ullah, Ihsan,Shah, Rehmat,Khan, Ikhtiar,Sewell, Robert D. E.,Abbas, Ghulam 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl) piperidinium chloride], compound (II) [4-carbamoyl-1-(2- hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.
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Gowhar Ali,Fazal Subhan,Nazar Ul Islam,Nasir Ullah,Muhammad Shahid,Sami Ullah,Ihsan Ullah,Rehmat Shah,Ikhtiar Khan,Robert D. E. Sewell,Ghulam Abbas 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
The aim of the current study was to explorein vivo any relative gastroulcerogenic prospective propensityof newly synthesized nitrogen containing derivativesof salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albinorats. The experimental groups received the following oraltreatments daily for 6 days: group I saline control; group II,standard (aspirin) treatment group [150 mg/kg of bodyweight]; group III, test (compound I) treatment group [100,150 mg/kg]; group IV, test (compound II) treatment group[100, 150 mg/kg]. The results showed that in the case of theaspirin treated group and compound (I) [150 mg/kg], therewas a significant increase in gastric volume, free acidity,total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastricmucosa of these treated groups revealed detectable morphologicalchanges. Utilizing the same protocol, syntheticcompound (I) [100 mg/kg] and (II) [100, 150 mg/kg]exhibited no statistically significant ulcerogenic or cytotoxicproperties. A cyclooxygenase (COX) selectivity test indicatedthe preferential inhibition of COX-I and COX-IIenzymes by compounds (I) and (II). This study thereforeindicates that these synthetic compounds may possessreduced ulcerogenic potential and could be a functionalsubstitute to aspirin.
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