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Transdermal Delivery of Crocin Using Bacterial Nanocellulose Membrane
Mustapha Abba,Zaharah Ibrahim,Chun Shiong Chong,Nurliyana Ahmad Zawawi,Mohammed Rafiq Abdul Kadir,Abdul Halim Mohd Yusof,SAIFUL IZWAN ABD RAZAK 한국섬유공학회 2019 Fibers and polymers Vol.20 No.10
This work reports the inclusion of crocin (an active agent of saffron) into bacterial nanocellulose (BNC) membranefor transdermal drug delivery. The BNC showed good uptake of the crocin based on the swelling studies and vibrationalpeaks of the FTIR spectra. Surface morphology of the crocin loaded BNC showed that the fibrous nano feature was still intactwith no fiber damages. The crocin release via direct dissolution showed typical burst release. Franz diffusion test revealedstable and prolong drug permeation. Partition coefficient of the BNC-crocin via mice epidermal skin diffusion was found tobe 2.44×10-4 cm-2 min-1 with the average mass flux of 0.53 cm-2 min-1. This facile method of utilizing BNC for the carrier ofcrocin can be useful for administrating other water soluble active compound. Thus BNC opens up choices for the delivery ofcrocin for medicinal purposes.