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Vildan Altunayoglu Cakmak,Sibel Gazioglu,Nuray Can Usta,Ahmet Ayar,Murat Topbas,Cavit Boz,Evrim Ozkorumak 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.4
Background and Purpose Restless legs syndrome (RLS) is a common sleep-related movement disorder that is frequently associated with psychological disturbances. Personality traitsare of considerable importance with respect to coping with chronic illness and disease vulnerability. This study assessed the temperament and character traits of RLS patients using an approach that involves the psychobiological model of personality. Methods The personality features of 65 newly diagnosed and untreated RLS patients with noneurological or psychiatric diseases and 109 healthy controls were determined using the Temperament and Character Inventory and compared using covariance analyses. The InternationalRLS Study Group Severity Scale was used to assess the severity of the RLS symptoms, and theBeck Depression Inventory was used to assess the presence and severity of depressive symptoms. Results RLS patients scored significantly higher than healthy controls on the temperamentdimension of harm avoidance (HA, p=0.02) and significantly lower on self-directedness (SD,p=0.001). No significant difference was observed in terms of the temperament dimension ofnovelty seeking (p=0.435). HA scores were significantly correlated with the BDI score but notwith the RLS severity or duration. Conclusions High HA and low SD scores are the main characterizing personality features ofRLS patients. These personality dimensions may be among the factors predisposing patients todevelopment of the depressive symptoms that are frequently associated with RLS.
Protective Effect of Melatonine Against Radiation Induced Nephrotoxicity in Rats
Kucuktulu, Eda,Yavuz, Aydin Ali,Cobanoglu, Umit,Yenilmez, Engin,Eminagaoglu, Selcuk,Karahan, Caner,Topbas, Murat,Kucuktulu, Uzer Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Purpose: The degree of radiation injury to kidneys which are located within the limits of radiotherapy area is determined by the volume and the dose of radiation to which the organ is exposed. When the tolerance dose of the kidney is exceeded after a latent period of 6 months acute nephritis develops and after 18 months chronic nephritis ensues. Melatonin is known to prevent the oxidative injury of toxins and radiotherapy with its free radical scavenging capacity. Methods and Materials: In this study 8 weeks old 24 Sprague -Dawley rats were allocated into 4 groups: Control group; Radiotherapy group (20 Gy bilaterally in 5 fractions); Melatonin group (10 mg/kg intraperitoneally), and Melatonin+radiotherapy group (20 Gy Radiotherapy in 5 fractions+ melatonin 10 mg/kg intraperitoneally). After a follow-up period of 6 months BUN was determined in all groups. After rats were euthanized the kidneys were removed for histopathological examination under both light and electron microscopes. Results: After 6 months follow-up, both at light and electron microscopy levels, the rats in radiotherapy+melatonin group were significantly protected against the radiation injury comparing to radiotherapy group (p<0.05). Conclusion: It was shown in this experimental model that melatonin has protective effects against radiation injury to kidneys.