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RISS 인기검색어
- 검색키워드
- 저자 : Mohammad Hossein Harirchian (검색결과 2 건)
- 무료
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Kimiya Rastegari,Mokhtari-Dizaji Manijhe,Mohammad Hossein Harirchian,Hassan Hashemi,Niloofar Ayoobi Yazdi,Hazhir Saberi 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.1
Purpose: Investigations of the hemodynamic changes of the venous system in patients with multiple sclerosis (MS) have shown contradictory results. Herein, the biomechanical parameters of the internal jugular vein (IJV) and common carotid artery (CCA) of MS patients were extracted and compared to healthy individuals. Methods: B-mode and Doppler sequential ultrasound images of 64 IJVs and CCAs of women including 22 healthy individuals, 22 relapsing-remitting multiple sclerosis (RRMS) patients, and 20 primary-progressive multiple sclerosis (PPMS) patients were recorded and processed. The biomechanical parameters of the IJV and the CCA walls during three cardiac cycles were calculated. Results: The IJV maximum and minimum pressures were higher in the MS patients than in the healthy subjects, by 31% and 19% in RRMS patients and 39% and 24% in PPMS patients. The venous wall thicknesses in RRMS and PPMS patients were 51% and 60% higher than in healthy subjects, respectively. IJV distensibility in RRMS and PPMS patients was 70% and 75% lower, and compliance was 40% and 59% lower than in healthy subjects. The maximum intima-media thicknesses of the CCAs were 38% and 24%, and the minimum intima-media thicknesses were 27% and 23% higher in RRMS and PPMS patients than in healthy individuals, respectively. The shear modulus of CCA walls in RRMS and PPMS patients was 17% and 31%, and the radial elastic moduli were 47% and 9% higher than in healthy individuals. Conclusion: Some physical and biomechanical parameters of the CCA and IJV showed significant differences between MS patients and healthy individuals.
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Nasibeh Amirzagar,Shahriar Nafissi,Abbas Tafakhori,Amirhossein Modabbernia,Aliakbar Amirzargar,Majid Ghaffarpour,Bahaddin Siroos,Mohammad Hossein Harirchian 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.2
Background and Purpose Te aim of this study was to determine the efcacy and tolerability of granulocyte colony-stimulating factor (G-CSF) in subjects with amyotrophic lateralsclerosis (ALS). Methods Forty subjects with ALS were randomly assigned to two groups, which received either subcutaneous G-CSF (5 μg/kg/q12h) or placebo for 5 days. Te subjects were then followed up for 3 months using the ALS Functional Rating Scale-Revised (ALSFRS-R), manualmuscle testing, ALS Assessment Questionnaire-40, and nerve conduction studies. CD34+/CD133+ cell count and monocyte chemoattractant protein-1 (MCP-1) levels were evaluated atbaseline. Results Te rate of disease progression did not difer signifcantly between the two groups. Te reduction in ALSFRS-R scores was greater in female subjects in the G-CSF group than intheir counterparts in the placebo group. Tere was a trend toward a positive correlation between baseline CSF MCP-1 levels and the change in ALSFRS-R scores in both groups (Spearman’s ρ=0.370, p=0.070). Conclusions With the protocol implemented in this study, G-CSF is not a promising optionfor the treatment of ALS. Furthermore, it may accelerate disease progression in females.
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