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RISS 인기검색어
- 검색키워드
- 저자 : Michiaki Takagi (검색결과 2 건)
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SUMRAY: R and Python Codes for Calculating Cancer Risk Due to Radiation Exposure of a Population
Sasaki Michiya,Furukawa Kyoji,Satoh Daiki,Shimada Kazumasa,Kudo Shin’ichi,Takagi Shunji,Takahara Shogo,Kai Michiaki 대한방사선방어학회 2023 방사선방어학회지 Vol.48 No.2
Background : Quantitative risk assessments should be accompanied by uncertainty analyses of the risk models employed in the calculations . In this study, we aim to develop a computational code named SUMRAY for use in cancer risk projections from radiation exposure taking into ac- count uncertainties . We also aim to make SUMRAY publicly available as a resource for further improvement of risk projection . Materials and Methods : SUMRAY has two versions of code written in R and Python . The risk models used in SUMRAY for all-solid-cancer mortality and incidence were those published in the Life Span Study of a cohort of the atomic bomb survivors in Hiroshima and Nagasaki . The confidence intervals associated with the evaluated risks were derived by propagating the statisti- cal uncertainties in the risk model parameter estimates by the Monte Carlo method . JRPR Results and Discussion : SUMRAY was used to calculate the lifetime or time-integrated attrib- utable risks of cancer under an exposure scenario (baseline rates , dose[s] , age[s] at exposure , age at the end of follow-up, sex) specified by the user. The results were compared with those calculated using another well-known web-based tool , Radiation Risk Assessment Tool (Rad- RAT; National Institutes of Health) , and showed a reasonable agreement within the estimated confidential interval . Compared with RadRAT, SUMRAY can be used for a wide range of ap- plications , as it allows the risk projection with arbitrarily specified risk models and/or popula- tion reference data . Conclusion : The reliabilities of SUMRAY with the present risk-model parameters and their variance-covariance matrices were verified by comparing them with those of the other codes . The SUMRAY code is distributed to the public as an open-source code under the Massachusetts Institute of Technology license .
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Suran Yang,Yuya Takakubo,Shinji Kobayashi,Tamon Asano,Akiko Sasaki,Kan Sasaki,Hiroharu Ohki,Yasunobu Tamaki,Michiaki Takagi 대한정형외과학회 2012 Clinics in Orthopedic Surgery Vol.4 No.3
Background: Minocycline-induced pigmentation of bone (black bone) is well described in tooth-bearing intra-oral bone, but is less known in periarticular bone in patients who have undergone total joint arthroplasty. On a retrospective basis, we investigated the short-term clinico-radiological results of total joint arthroplasties in which the patient developed minocycline-induced periarticular black bone. Methods: We found 5 cases (0.08%), in 4 patients, of periarticular bone pigmentation revealed during total joint arthroplasties (2 hips, 2 knees, and 1 ankle) in our series of total joint surgeries (6,548 cases) over a 10-year time period in our 3 institutes. Their mean age was 56 years at surgery. All patients had received long-term minocycline treatment. Mean dosage and duration of minocycline was 160 mg/day and 2.2 years, respectively. Minocycline had been prescribed for reactive arthritis (one), rheumatoid arthritis (two) and late infection after total joint arthroplasty (two patients). Mean follow-up period was 3.4 years after the surgeries. Results: All cases had black or brown pigmentation in the periarticular bones during the surgery. There was no pigmentation in the cartilage or soft tissues of the joints. The mean Japanese Orthopaedic Association (JOA) score or Japanese Society for Surgery of the Foot (JSSF) scale for rheumatoid arthritis foot and ankle joints at latest follow-up (case 1, 66; case 2, 87; case 3, 77; case 4, 77; case 5, 80) improved compared to those of pre-surgery (case 1, 47; case 2, 45; case 3, 55; case 4, 34; case 5, 55). No implant loosening was noted on radiographic examination during the follow-up period. No abnormal bone formation, bone necrosis, hemosiderin deposition, malignancy or metallic debris was found on histological examination. Conclusions: No clinico-radiological symptoms of total joint arthroplasties showed in the patients with minocycline-induced periariticular black bone in the short-term. Systemic minocycline treatment has the potential to induce significant black pigmentation of many tissues. In particular, minocycline-induced pigmentation of periarticular bone may be accelerated by inflammation due to rheumatic or pyogenic arthritis. Surgeons should recognize the risk of bone pigmentation in inflamed joints due to the systemic treatment of minocycline and explore its influence on periarticular bone and total joint arthroplasty in the long-term.
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