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Lymphangiectatic Variant of Low Grade Malignant Eccrine Spiradenoma
Gizem Akkas Akgun,Anvar Ahmedov,Ali İhsan Parlar,Mehmet Hüseyin Metineren,Ayse Nur Deger 대한피부과학회 2023 Annals of Dermatology Vol.35 No.1
Low-grade malignant eccrine spiradenoma (spiradenocarcinoma) is a rare sweat glandtumor, which usually arises from a pre- existing benign eccrine spiradenoma. This paperpresents the case of a 55-year-old male who had a lesion in his right elbow for 10 years. Themicroscopic examination revealed a well-demarcated, multilobulated tumor in the dermisand subcutis, which presented with many blood-filled vessels and extensive hemorrhage. The tumor was composed of hyperchromatic, round to oval cells with nucleolar prominence,mild to moderate atypia, and increased mitotic index. Additionally, lymphangiectaticappearance was observed in areas with prominent stromal lymphedema. P53 and Ki-67 hadhigh positivity. Surgical excision of the lesion was performed with adequate surgical margins,and the dissected lymph nodes in the axilla were tumor-negative. After 15 months offollow-up, there was no recurrence or distant metastasis.