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        Artificial Intelligence Increases the Agreement among Physicians Classifying Focal Skeleton/Bone Marrow Uptake in Hodgkin’s Lymphoma Patients Staged with [18F]FDG PET/CT—a Retrospective Study

        May Sadik 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.2

        Purpose Classification of focal skeleton/bone marrow uptake (BMU) can be challenging. The aim is to investigate whether anartificial intelligence–based method (AI), which highlights suspicious focal BMU, increases interobserver agreement amonga group of physicians from different hospitals classifying Hodgkin’s lymphoma (HL) patients staged with [18F]FDG PET/CT. Methods Forty-eight patients staged with [18F]FDG PET/CT at Sahlgenska University Hospital between 2017 and 2018 werereviewed twice, 6 months apart, regarding focal BMU. During the second time review, the 10 physicians also had access toAI-based advice regarding focal BMU. Results Each physician’s classifications were pairwise compared with the classifications made by all the other physicians,resulting in 45 unique pairs of comparisons both without and with AI advice. The agreement between the physicians increasedsignificantly when AI advice was available, which was measured as an increase in mean Kappa values from 0.51 (range0.25–0.80) without AI advice to 0.61 (range 0.19–0.94) with AI advice (p = 0.005). The majority of the physicians agreedwith the AI-based method in 40 (83%) of the 48 cases. Conclusion An AI-based method significantly increases interobserver agreement among physicians working at differenthospitals by highlighting suspicious focal BMU in HL patients staged with [18F]FDG PET/CT.

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