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Rehabilitation Support Robot for Self-Standing-Up Training of Hemiplegic Stroke Patients
Masateru Saito,Mizuki Kitamura,Yoshifumi Morita,Hirofumi Tanabe,Yukio Kobayashi,Takafumi Iziri,Hiroyuki Daiko,Naoki Kiriyama 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
The objective of the study involves developing a rehabilitation support robot for self-standing-up training of hemiplegic stroke patients to restore normal standing-up motion. Therapist-guided standing-up training is effective in improving the motor function of a patient’s paralyzed leg. The therapist controls a patient’s left/right load balance by pulling or pushing the patient’s waist during standing-up training. Hence, we investigated the relationship between the patient’s waist movement and the left/right load balance during guided standing-up motion. The analysis results revealed the ideal pattern of the load balance ratio during guided standing-up training. In addition, the results indicate that the patient’s waist movement corresponded to the ideal pattern of the load balance ratio. It is expected that this movement trajectory is useful in designing a controller of a rehabilitation support robot. In order to reproduce the therapist-guided standing-up training with a rehabilitation support robot, it is necessary to consider a control method that can be installed on the robot.
Masahiko Kobayashi,Jian Xu,Kohei Kakino,Akitsu Masuda,Masato Hino,Naoki Fujimoto,Kosuke Minamihata,Noriho Kamiya,Hiroaki Mon,Hiroshi Iida,Masateru Takahashi,Takahiro Kusakabe,이재만 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.1
Interleukine-4 (IL-4) is a cytokine that plays an important role in the immune system and recognized as a biological medicine. Therefore, there is a demand for the production of IL-4 with high performance. The expression of a recombinant IL-4 protein in the prokaryotic system usually results in the formation of an inclusion body. To date, the solution to obtain those active products without the refolding process remains to be established. In this study, we tried to acquire a biologically active recombinant Mus musculus IL-4 (rMmIL-4) using a silkworm-baculovirus expression vector system (silkworm-BEVS). We constructed two recombinant baculoviruses coding rMmIL-4 with the distinct location of affinity purification tags and succeeded in the expression and purification of rMmIL-4 proteins directly without the refolding process. Both purified proteins displayed comparable biological activity to the commercial proteins produced by the E. coli expression system. Besides, we performed screening of silkworm strains to seek optimal hosts for the mass-production of rMmIL-4. Intriguingly, we found that some silkworm strains showed significantly higher secretion levels of rMmIL-4 in silkworm sera. Our study provides meaningful insights into the industrial-scale production of rMmIL-4 with high productivity for pharmaceutical applications in the future.