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        Hypoalbuminemia as a risk factor for thromboembolic events in inflammatory bowel disease inpatients

        Marcello Rabello Imbrizi,Daniela Oliveira Magro,Tirzah de Mendonça Lopes Secundo,Marlone Cunha-Silva,Paulo Gustavo Kotze,Ciro Garcia Montes,Jazon Romilson de Souza Almeida,Virgínia Lúcia Ribeiro Cabra 대한장연구학회 2019 Intestinal Research Vol.17 No.1

        Background/Aims: Inflammatory bowel disease (IBD) are chronic entities characterized by local and systemic inflammationand may be associated with thrombosis. The aim of this study was to identify the prevalence of thromboembolic events (TEE)in hospitalized IBD patients and identify risk factors for their occurrence. Methods: This retrospective, single-center study includedpatients treated at a Brazilian IBD referral unit between 2004 and 2014. Patients hospitalized for more than 48 hoursdue to active IBD and who did not receive prophylaxis for TEE during hospitalization were included. Patients were allocated to2 groups: those with TEE up to 30 days or at the time of hospitalization (TEE-group) and patients without TEE (control-group). Clinical and laboratory characteristics were evaluated. Results: Of 53 patients evaluated, 69,8% with Crohn’s disease (CD) and30.2% with ulcerative colitis (UC). The prevalence of TEE 30 days before or during hospitalization was 15.1%, with 10.8% in CDand 25% in UC. In the TEE group, mean serum albumin was 2.06 g/dL versus 3.30 g/dL in the control group. Patients with albuminlevels below 2.95 g/dL (43.18%) had a higher risk of developing TEE (relative risk, 1.72; 95% confidence interval, 1.17–2.53)(P<0.001). Conclusions: Albumin levels were significantly lower in patients with TEE, and hypoalbuminemia was considered arisk factor for the development of TEE in this population. (Intest Res 2019;17:63-69)

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