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Mark L. Failla,Raghu Pullakhandam 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
The leaves and pods of the drumstick tree are used as food and medicine in some Asian and African coun-tries. Although relatively high concentrations of .-carotene and lutein have been reported in the leaves, the bioavailability ofthese carotenoids from this source is unknown. We have analyzed the digestive stability and bioaccessibility of carotenoidsin fresh and lyophilized drumstick leaves using the coupled in vitrodigestion/Caco-2 cell model. .-Carotene and lutein were
Siriporn Tuntipopipat,Channarong Muangnoi,Mark L. Failla 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6
Nitric oxide (NO) and tumor necrosis factor-α (TNF-α) play important roles in inflammatory processes. This study examined whether 13 spices/herbs commonly used in Thai dishes modulate the production of NO and TNF-α by the RAW 264.7 mouse macrophage cell line pretreated with plant extracts (1–100μg/mL) prior to activation by bacterial lipopolysaccharide (LPS). Tested plant tissues were extracted with ethanol with the exception of roselle, which was extracted with 70% acetone. Eight of the 13 plant extracts inhibited NO and TNF-α production in a dose-dependent manner without exerting cytotoxicity. Extract from Limnophila aromatica (Kyeng) was the most robust suppressor of NO production, followed by dill, kaffer lime, chili, Teaw, mint, sweet basil, and pea eggplant, respectively (range of 50% inhibitory concentration [IC50]=11.4–74.6μg/mL). Kyeng also exhibited the greatest inhibition of TNF-α production (IC50=10.5μg/mL). IC50 values for NO and TNF-α production in LPS-activated RAW 264.7 cells for these extracts were highly correlated (r=0.772, P=.025). These results suggest that extracts from some spices/herbs in the habitual Thai diet possess anti-inflammatory activity. Moreover, the results support the use of NO production in LPS-activated RAW 264.7 cells as a rapid and cost-effective tool for screening the anti-inflammatory activity of extracts of spices/herbs.