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Rebeka Tomasin,Rafael Siqueira de Andrade,Maria Cristina Cintra Gomes-Marcondes 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.10
Oxidative stress has a dual role in cancer; it is linkedwith tumorigenic events and hostwasting, aswell as senescence and apoptosis. Researchers have demonstrated the importance of coadjuvant therapies in cancer treatment, and Aloe vera and honey have immunomodulatory, anticancer, and antioxidant properties. The preventive and therapeutic effects of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and honey in tumor progression and host wasting were analyzed in Walker 256 carcinoma-bearing rats. The animalswere distributed into the following groups:C= control-untreated,W= tumor-untreated,WA= treated after tumor induction, A= control-treated, AW= treated before tumor induction, and AWA= treated before and after tumor induction. Proteolysis and oxidative stress were analyzed in the tumor, liver, muscle, and myocardial tissues. The results suggest that the Aloe vera and honey treatment affect the tumor and host by different mechanisms; the treatment-modulated host wasting and cachexia, whereas it promoted oxidative stress and damage in tumor tissues, particularly in a therapeutic context (WA).