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RISS 인기검색어
- 검색키워드
- 저자 : Marcella Margiotta (검색결과 2 건)
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Claritromycin Resistance and Helicobacter pylori Genotypes in Italy
Francesco Vincenzo De,Margiotta Marcella,Zullo Angelo,Hassan Cesare,Valle Nicolar Della,Burattini Osvaldo,D'Angel Roberto,Stoppino Giuseppe,Cea Ugo,Giorgio Floriana,Monno Rosa,Morini Sergio,Panella Ca The Microbiological Society of Korea 2006 The journal of microbiology Vol.44 No.6
The relationship between H. pylori clarithromycin resistance and genetic pattern distribution has been differently explained from different geographic areas. Therefore, we aimed to assess the clarithromycin resistance rate, to evaluate the bacterial genetic pattern, and to search for a possible association between clarithromycin resistance and cagA or vacA genes. This prospective study enrolled 62 consecutive H. pylori infected patients. The infection was established by histology and rapid urease test. Clarithromycin resistance, cagA and vacA status, including s/m subtypes, were assessed on paraffin-embedded antral biopsy specimens by TaqMan real time polymerase chain reaction (PCR). Primary clarithromycin resistance was detected in 24.1 % of cases. The prevalence of cagA was 69.3%, and a single vacA mosaicism was observed in 95.1 % cases. In detail, the s1m1 was observed in 23 (38.9%) patients, the s1m2 in 22 (37.2%), and the s2m2 in 14 (23.7%), whereas the s2m1 combination was never found. The prevalence of cagA and the vacA alleles distribution did not significantly differ between susceptible and resistant strains. Primary clarithromycin resistance is high in our area. The s1m1 and s1m2 are the most frequent vacA mosaicisms. There is no a relationship between clarithromycin resistance and bacterial genotypic pattern and/or cagA positivity.
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Claritromycin Resistance and Helicobacter pylori Genotypes in Italy
Vincenzo De Francesco,Marcella Margiotta,Cesare Hassan,Nicola Della Valle,Osvaldo Burattini,Roberto D’Angelo,Giuseppe Stoppino,Ugo Cea,Floriana Giorgio,Rosa Monno,Sergio Morini,Carmine Panella,Enzo Ie 한국미생물학회 2006 The journal of microbiology Vol.44 No.6
The relationship between H. pylori clarithromycin resistance and genetic pattern distribution has been differently explained from different geographic areas. Therefore, we aimed to assess the clarithromycin resistance rate, to evaluate the bacterial genetic pattern, and to search for a possible association between clarithromycin resistance and cagA or vacA genes. This prospective study enrolled 62 consecutive H. pylori infected patients. The infection was established by histology and rapid urease test. Clarithromycin resistance, cagA and vacA status, including s/m subtypes, were assessed on paraffin-embedded antral biopsy specimens by TaqMan real time polymerase chain reaction (PCR). Primary clarithromycin resistance was detected in 24.1% of cases. The prevalence of cagA was 69.3%, and a single vacA mosaicism was observed in 95.1% cases. In detail, the s1m1 was observed in 23 (38.9%) patients, the s1m2 in 22 (37.2%), and the s2m2 in 14 (23.7%), whereas the s2m1 combination was never found. The prevalence of cagA and the vacA alleles distribution did not significantly differ between susceptible and resistant strains. Primary clarithromycin resistance is high in our area. The s1m1 and s1m2 are the most frequent vacA mosaicisms. There is no a relationship between clarithromycin resistance and bacterial genotypic pattern and/or cagA positivity.
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