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- 저자 : Mallika Sanyal (검색결과 1 건)
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Vijay D. Chavada,Nejal M. Bhatt,Mallika Sanyal,Pranav S. Shrivastav 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.84 No.-
In the present work, a simple approach for colorimetric determination of allopurinol and its majormetabolite oxypurinol is presented using gold nanoparticles as a probe. Gold nanoparticles weresynthesized using the citrate reduction method and then functionalized using melamine (mel-AuNPs). The nanoparticles were characterized using UV–vis spectrophotometry, dynamic light scattering andtransmission electron microscopy. The bare AuNPs capped with citrate anions (cit-AuNPs) gave a linearresponse towards allopurinol and oxypurinol within the range 0.20–40.0 mM and 0.25–25.0 mMrespectively; however the melamine functionality on the AuNPs exhibited specific response foroxypurinol from 0.10 to 15.0 mM. This enabled development of a simple approach for the quantitation ofthe metabolite using mel-AuNPs, while the quantitation of allopurinol was carried out using theregression parameters of cit-AuNPs and the calculated amount of metabolite. For method optimizationparameters such as the pH, incubation time and effect of ionic strength of the medium which can causeaggregation of nanoparticles were studied. The methodology was found to yield reliable results asevident from the validation results. The application of the method is demonstrated by analyzingallopurinol from tablet formulations and the drug and its metabolite from spiked plasma samples.
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