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PC-766B' and PC-766B, 16-Membered Macrolide Angiogenesis Inhibitors Produced by Nocardia sp. RK97-56
KO, HACK-RYONG,KAKEYA, HIDEAKI,YOSHIDA, ARIKA,ONOSE, RIE,UEKI, MASASHI,MUROI, MAKOTO,TAKATSUKI, AKIRA,MATSUZAKI, HIROSHI,OSADA, HIROYUKI 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.5
Angiogenesis is an essential event in a variety of physiological and pathological processes. Therefore, effective inhibition of event is a promising strategy for treating angiogenesis-related diseases, including cancer. The current study investigated two unique bafilomycin-type macrolide inhibitors of angiogenesis, PC-766B' (1) and PC-766B (2). The strain RK97-56 which produced the inhibitors was identified as Nocardia sp. by chemotaxonomic analyses, and the purification of the inhibitors was guided by their anti-angiogenic actives. PC-766B' (1) and PC-766B (2) exhibited potent inhibitory activities towards endothelial cell migration stimulated by the vascular endothelial growth factor(VEGF).
Ergonomic evaluation on wheel-scrolling motions for reducing the risk of musculoskeletal disorders
Hiroki Maniwa,Makoto Osada,Kentaro Kotani,Takafumi Asao,Satoshi Suzuki 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.5
The objective of this study is to find characteristics of wheel scrolling motions and to control such characteristics to observe whether or not subjective symptoms associated with musculoskeletal disorders were reduced. Wheel scrolling motions were obtained by a high-speed video camera and changes in joint angles and subjective evaluations for muscular loads were monitored. Susceptible characteristics of musculoskeletal disorders were enumerated by analyzing dynamic changes in finger joint angles and two mouse prototypes to reduce such characteristics were produced for evaluation. As a result, muscular loads were higher when subjects performed scroll-up motions (SU) than scroll-down motions (SD). Unnecessary finger motions with potentially awkward posture were also found during SU motions. Muscular loads during SU motions seemed related to the awkward postures of the finger. All in all, it was revealed that such awkward posture lead to the muscular loads.
Violaceols function as actin inhibitors inducing cell shape elongation in fibroblast cells.
Asami, Yukihiro,Jang, Jae-Hyuk,Oh, Hyuncheol,Sohn, Jae Hak,Kim, Jong Won,Moon, Dong Oh,Kwon, Osong,Kawatani, Makoto,Osada, Hiroyuki,Kim, Bo Yeon,Ahn, Jong Seog Japan Society for Bioscience, Biotechnology, and A 2012 Bioscience, biotechnology, and biochemistry Vol.76 No.8
<P>Violaceol-I and -II were isolated from a fractionated library of marine-derived fungal metabolites. These compounds increased the calcium ion concentration inside the cell and caused F-actin aggregation in rat fibroblast 3Y1 cells within 3 h resulting in cell shape elongation. Calcium chelator BAPTA-AM (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis (acetoxymethyl ester) inhibited violaceol-I and -II induced F-actin aggregation in 3Y1 cells, and hence violaceol-I and -II act in a calcium dependent manner. Violaceol-I and -II inhibited G-actin polymerization in vitro in a dose-dependent manner and strongly associated with G-actin, at dissociation equilibrium constants of 1.44 ?? 10(-8) M and 2.52 ?? 10(-9) M respectively. Here we report the identification of a novel function of violaceol-I and -II as actin inhibitors. Violaceol-I and -II induced cell shape elongation through F-actin aggregation in 3Y1 fibroblasts. These compounds may give researchers new insights into the role of actin in tumorigenesis and lead to the development of additional anti-tumor drugs.</P>
Fusarisetin A, an Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326
Jang, Jae-Hyuk,Asami, Yukihiro,Jang, Jun-Pil,Kim, Sun-Ok,Moon, Dong Oh,Shin, Kee-Sun,Hashizume, Daisuke,Muroi, Makoto,Saito, Tamio,Oh, Hyuncheol,Kim, Bo Yeon,Osada, Hiroyuki,Ahn, Jong Seog American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.18
<P>An acinar morphogenesis inhibitor named fusarisetin A (<B>1</B>) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of <B>1</B> was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-18/ja1110688/production/images/medium/ja-2010-110688_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja1110688'>ACS Electronic Supporting Info</A></P>