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        Inhibition of Nicotine-Induced Toxicity by Curcumin and Curcumin Analog: A Comparative Study

        M. Amarnath Satheesh,Venugopal P. Menon 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.4

        The present study was undertaken to evaluate the effects of curcumin and curcumin analog on blood oxi-dantantioxidant status during nicotine-induced toxicity in male Wistar rats. Lung toxicity was induced by subcutaneous in-jection of nicotine at a dose of 2.5 mg/kg of body weight (5 days a week, for 22 weeks). The enhanced circulatory lipid per-oxides in nicotine-treated rats was accompanied by a significant decrease in the levels of ascorbic acid, vitamin E, reducedglutathione, glutathione peroxidase, superoxide dismutase, and catalase. There was a reduction in the levels of zinc with anelevation of copper and ferritin in nicotine-treated rats. Administration of curcumin and curcumin analog significantly low-ered the lipid peroxidation and enhanced the antioxidant status with modulation in the levels of zinc, copper, and ferritin.However, the effect was more significant in curcumin analog-treated rats than in curcumin-treated rats. The results of the pres-ent study suggest that curcumin and curcumin analog exert their protective effects by modulating the extent of lipid peroxi-dation and enhancing the antioxidant status.

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