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- 저자 : Luyu Zhang (검색결과 4 건)
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Lei Fang,Zhang Huimin,Luo Rui,Fei Qingsong,Bai Luyu,He Ning 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.5
Purpose The present study was designed to formulate a thermoreversible in situ gel system for sustained ocular delivery of desmopressin acetate (DDAVP) for the treatment of polyuria. Methods The cold method was employed for the preparation of in situ gel formulations using different levels of poloxamer 407 (F-127) and carboxymethyl chitosan (CMCTS). The optimal formulation was selected based on gelation temperature, rheological behavior, and in vitro drug release, and further evaluated by thermal, ocular irritation, residence time, in vivo pharmacokinetics, and pharmacodynamic analyses. Results The optimal formulation, composed of F-127 (20%) and CMCTS (1.5%), showed appropriate fluidity at room temperature (25 °C) and transitioned to semisolid gels at physiological temperature (34 °C). The optimal gels showed pseudoplastic fluid properties and favorable thixotropy characteristics in rheological tests. Differential scanning calorimetry analysis revealed even dispersal of DDAVP in the matrix of gels. Results from in vivo studies demonstrated that the newly prepared gel successfully prolonged the residence time of DDAVP, improved ocular bioavailability, and exerted the same antidiuretic effect as ophthalmic drops. Conclusion The developed thermoreversible ophthalmic in situ gel of DDAVP presents a promising formulation for the treatment of polyuria.
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Low-Frequency Vibration Control of Metro Slab Track Based on Locally Resonant Theory
Chao Li,Sifeng Zhang,Qian Liu,Chong Zhou,Haichao Qin,Luyu Zhang,Minghu Zhai 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.6
Vibration control has always been one of the research hotspots in the field of urban metro system. Due to the unsatisfactory application effect of traditional vibration damping technology in practice, a novel method, based on the locally resonant theory, was introduced into metro vibration damping system to improve the low-frequency vibration reduction effect. Meanwhile, the new metro vibration reduction slab track was designed. Furthermore, the coupled model of the metro vehicle-slab track was established and verified, and the reduction effect of the new metro slab track on low-frequency vibration under the action of metro vehicles was analyzed. Results show that: 1) The new vibration reduction slab track is really in control of the low-frequency vibration (50 − 100 Hz), and the attenuation effect can reach 10 dB; 2) The new slab track has multiple low-frequency vibration band gaps, which can achieve multi-frequency vibration reduction; 3) The new slab track can reduce the vibration acceleration of the track, which can improve the comfort level of the vehicle. Therefore, the local resonance theory enriches the existing metro vibration reduction design theory and provides a method for the design of the metro vibration control.
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Lanzi Cheng,Rui Zhang,Weixin Lv,Luyu Shao,Zheng Wang,Wei Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2020 NANO Vol.15 No.03
Highly efficient, cost-effective and durable electrocatalysts for water splitting are crucial for energy conversion and storage. Transition-metal phosphides have been proven to be efficient catalysts for water splitting. In this paper, surface phosphation of 3D NiCo2O4 nanowires grown on Ni foam (P-NiCo2O4/NF) have been prepared to investigate the effect of surface phosphating on catalyst activity. XRD and XPS results demonstrate that P element has been decorated on the surface of the NiCo2O4 nanowires. The electrochemical results prove that P-NiCo2O4/NF shows better electrochemical performance than pure NiCo2O4/NF as an electrode for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) of water splitting. It achieves a current density of 10 mA cm2 at an overpotential of 279 mV and 164 mV for OER and HER in 1.0 M KOH electrolyte, respectively. In addition, the P-NiCo2O4/NF || P-NiCo2O4/NF electrode is constructed by employing P-NiCo2O4/NF as both the anode and cathode, it only requires a low 1.68 V of cell voltage to reach the current density of 10 mA cm -2. Notably, P-NiCo2O4/NF||P-NiCo2O4/NF also exhibits excellent stability for over 30 h-long. These results indicate that surface phosphation is an effective approach to improve the electrochemical performance of NiCo2O4/NF electrode materials.
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Lack of Association Between CYP1A1 Polymorphisms and Risk of Bladder Cancer: a Meta-analysis
Lu, Yu,Zhang, Xiao-Lian,Xie, Li,Li, Tai-Jie,He, Yu,Peng, Qi-Liu,Deng, Yan,Wang, Jian,Qin, Xue,Li, Shan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9
Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Material and Methods: A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Results: Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. Conclusion: The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.
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