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RISS 인기검색어
- 검색키워드
- 저자 : Libo Shi (검색결과 2 건)
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Cell Division Cycle Associated 8 Is a Key Regulator of Tamoxifen Resistance in Breast Cancer
Dehai Yu,Libo Shi,Yuhui Bu,Weidong Li 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: Breast cancer (BC) is one of the most common malignancies globally, and millions of women worldwide are diagnosed with BC every year. Up to 70% of BC patients are estrogen receptor (ER)-positive. Numerous studies have shown that tamoxifen has a significant therapeutic effect on both primary and metastatic ER-positive BC patients. Although tamoxifen is currently one of the most successful therapeutic agents for BC, a significant proportion of patients will eventually become resistant to tamoxifen, leading to tumor recurrence and metastasis. Knowledge about the development of tamoxifen resistance in BC patients is still limited. Methods: We applied a loss-and-gain method to study the biological functional role of cell division cycle associated 8 (CDCA8) in tamoxifen resistance in BC cells. Results: We found that CDCA8 was significantly elevated in tamoxifen-resistant BC cells. Knockdown of CDCA8 expression significantly inhibited the proliferation of tamoxifen-resistant BC cells and reduced their resistance to tamoxifen. In contrast, overexpression of CDCA8 promoted the growth of tamoxifen-sensitive BC cells and induced their resistance to tamoxifen. Conclusion: In this study, we reported that CDCA8 is a key regulator of tamoxifen resistance in BC, suggesting that CDCA8 may serve as a potential therapeutic target for BC treatment.
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Xiangyang Zhou,Yanjun Shi,Lingling Li,Rui-fang Yu,Libo Zhao 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.6
This paper presents a high precision compound control scheme based on non-singular terminal sliding mode and extended state observer (ESO) for an aerial inertially stabilized platform (ISP) to suppress the effects of multi-source disturbances on the control performance of the ISP. Firstly, a non-singular terminal sliding mode controller is proposed to achieve high disturbance rejection ability, by which the multi-source disturbances are integrally suppressed as an aggregate disturbance. And then, to restrain the chattering effect of the sliding mode control, a disturbance compensation scheme based on the extended state observer is proposed. By the ESO, the disturbances are observed and compensated in real time and hence the chattering effect is significantly alleviated. Meanwhile, a parameter configuration method is proposed to simplify the ESO design. To verify the method, simulations and experiments are conducted. The results show that the proposed compound control scheme has excellent ability in both disturbance rejection and chattering reduction, by which the stabilization precision of the ISP is improved significantly.
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