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- 저자 : Lalit Kishore (검색결과 2 건)
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Lalit Kishore,Randhir Singh 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.3
Diabetic nephropathy is a long-term complication of diabetes mellitus. Chronic hyperglycemia leads to the generation of reactive oxygen species leading to oxidative stress. Hyperglycemia and oxidative stress are involved in the development of diabetic nephropathy. This study was designed to evaluate the effect of homeopathic preparation of Gymnema sylvestre Mother tincture, 6C and 30 C potencies on diabetic nephropathy in Wistar rats. Diabetic nephropathy was induced by intraperitoneal injection of streptozotocin (60 mg/kg) 15 min after Nicotinamide (230 mg/kg, i.p.) administration. Rats were divided into six groups (n = 6). Group 1 and 2 was kept normal control and diabetic control respectively whereas Groups 3–5 consist of diabetic nephropathy rats treated with different doses of G. sylvestre Mother tincture, 6C and 30 C potencies for 45 days. Glimepride (10 mg/kg) was used as standard. Diabetic nephropathy was assessed by determining serum glucose, urea, uric acid, creatinine level and tissue histological examination. Tissue antioxidant enzymes (SOD, GSH, LPO) level was measured to assess the oxidative stress. Also the level of advanced glycation end products in kidney was determined. Mother tincture, 6C and 30 C potencies of G. sylvestre produced significant attenuation in the biochemical parameters used to assess diabetic nephropathy. Moreover, oxidative stress and AGE’s level in kidney was also found to be significantly reduced. So, it can be concluded that Mother tincture, 6C and 30 C potencies of G. sylvestre have protective effect against diabetic nephropathy via inhibition of Oxidative stress and AGE’s.
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Kumar, Gourav,Bhushan, Manindra,Kumar, Lalit,Kishore, Vimal,Raman, Kothanda,Kumar, Pawan,Barik, Soumitra,Purohit, Sandeep Korean Society of Medical Physics 2021 의학물리 Vol.32 No.3
Purpose: This study was designed to investigate the dosimetric difference between intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in head and neck cancer (HNC). The study primarily focuses on low-dose spillage evaluation between these two techniques. Methods: This retrospective study involved 45 patients with HNC. The treatment plans were generated using the IMRT and VMAT techniques for all patients. Dosimetric comparisons were performed in terms of target coverage, organ-at-risk (OAR) sparing, and various parameters, including conformity index, uniformity index, homogeneity index, conformation number, low-dose volumes, and normal tissue integral dose (NTID). Results: No significant (P>0.05) difference in planning target volume coverage (D<sub>95%</sub>) was observed between IMRT and VMAT plans for supraglottic larynx, hard palate, and tongue cancers. A decrease in dose volumes ranging from 1 Gy to 30 Gy was observed for VMAT plans compared with those for IMRT plans, except for V<sub>1Gy</sub> and V<sub>30Gy</sub> for supraglottic larynx cancer and V<sub>1Gy</sub> for tongue cancer. Moreover, decreases (P<0.05) in NTID were observed for VMAT plans compared with that for IMRT plans in supraglottic larynx (4.50%), hard palate (12.80%), and tongue (7.76%) cancers. In contrast, a slight increase in monitor units for VMAT compared with those for IMRT in supraglottic larynx (0.46%), hard palate (2.54%), and tongue (7.56%) cancers. Conclusions: For advanced-stage HNC, both IMRT and VMAT offer satisfactory clinical plans. VMAT offers a conformal and homogeneous dose distribution with comparable OAR sparing and higher dose falloff outside the target volume than IMRT, which provides an edge to reduce the risk of secondary malignancies for HNC over IMRT.
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