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Non-invasive brain temperature monitoring using MR thermometry: in-vivo validation study
KyungA Kwak,Bitnarae Kwak,Taeim Kim,Kyung Sik Yi,ChulHyun Lee,Chi-Hoon Choi 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Purpose Non-invasive monitoring of brain temperature is essential for the assessment and optimization of therapeutic target temperature in acute ischemic brain. MR thermometry using 1-H MR spectroscopy (MRT) with Thulium-DOTMA (Tm-DOTMA) has the advantage of allowing absolute temperature measurements. We tried to validate MRT by comparing it with the actual brain temperature in rats. Materials and Methods Serial MRT was obtained in rats with mild systemic hypothermia (Group 1, n=5) and rats with local brain hypothermia with endovascular cooling (Group 2, n=5). Fiber optic thermometry (FOT) was inserted into the brain parenchyma to measure the actual temperature of the brain before MRT scans. For the local brain hypothermia models a 26G jelco catheter was inserted into the ICA and cold saline (4℃, 20ml) was infused in the MR bore for 20 minutes, followed by serial MRTs for 60 minutes. During MRT scans, body temperature was monitored using FOT. Tm-DOTMA was infused into the external jugular vein prior to an induced hypothermia. All the spectral data were semi-automatically processed by phasing and baseline correction using Philips software and JMRUI (URL http://www.mrui.uab.es/mrui/). Results The measured serial temperatures of FOT and MRT showed a similar linear decline in the systemic and local hypothermia groups. The differences of the measured temperatures between two methods were 0.05 ± 0.24 ℃ (mean±SD) in systemimc hypothermia group and 0.14 ± 0.34 in local brain hypothermia group. Conclusion In this study, we validated the MRT can monitor the selective brain hypothermia by confirming an accurate measurement of the actual brain temperature. Non-invasive brain temperature monitoring using the MRT is expected to be an important imaging biomarker for appropriate therapeutic hypothermia in the acute stroke patients.