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Durable Response of Androgen Receptor-Positive Male Breast Cancer to Goserelin
Hamdy Abdel Azim,Loay Kassem,Kyrillus Samaan Shohdy,Boules Eshaak,Shady Elia Anis,Nermine Shawky Kamal 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1
The luteinizing hormone-releasing hormone/androgen receptor (LHRH/AR) pathway is a promising treatment target in a subgroup of female patients with triple-negative breast cancer (TNBC). However, very little is known about the efficacy of this strategy in male patients with TNBC. In this report, we describe a male patient with AR-positive TNBC who was successfully treated using an LHRH agonist after pretreatment with several lines of chemotherapy and achieved a durable response. We also review the existing evidence supporting LHRH- and AR-targeted therapy for this rare disease.