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관-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus.
Youn, Kumju,Jeong, Woo-Sik,Jun, Mira Taylor Francis Health Sciences 2013 NATURAL PRODUCT RESEARCH Vol.27 No.16
<P>In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against 관-secretase (BACE1) with 9.2????????10???? ???M and K(i) value of 5.5????????10???? M. Loganin exhibited less inhibitory activity to 관-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.</P>
Fatty Acid and Volatile Oil Compositions of Allomyrina dichotoma Larvae
Kumju Youn,Ji-Young Kim,Hyelim Yeo,Eun-Young Yun,Jae-Sam Hwang,Mira Jun 한국식품영양과학회 2012 Preventive Nutrition and Food Science Vol.17 No.4
Thirty-two different volatile oils were identified from Allomyrina dichotoma (A. dichotoma) larvae by gas chromatography/mass spectrometry (GC/MS). The major volatile components were 2,2,4-trimethyl-3-carboxyisopropyl pentanoic acid isobutyl ester (5.83%), phenol,2,6-bis(a,a-dimethyl ethyl)-4-(1-methyl-1-phenylethyl) (5.72%), heptacosane (5.49%) and phenol,2,4-bis(1-methyl-1-phenylethyl) (5.47%). The composition of the fatty acids in A. dichotoma larvae was also determined by gas chromatography (GC) and fourteen constituents were identified. Oleic acid (19.13%) was the most abundant fatty acid followed by palmitic acid (12.52%), palmitoleic acid (3.71%) and linoleic acid (2.08%) in 100 g of A. dichotoma larvae on a dry weight basis. The quantity of unsaturated fatty acids (64.00%) were higher than that of saturated ones (36.00%). The predominant fatty acids in A. dichotoma consist of monounsaturated fatty acid (MUFA, 57.70%) such as oleic acid, myristoleic acid and palmitoleic acid, followed by saturated fatty acids (36.00%) and polyunsaturated fatty acids (PUFA, 6.50%). In particular, the presence of essential fatty acids, such as linoleic (5.30%) and linolenic acid (0.40%) give A. dichotoma larvae considerable nutritional and functional value and it may be a useful source for food and/or industrial utilization.