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- 저자 : Kolter, Karl (검색결과 1 건)
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McFall, Haley,Sarabu, Sandeep,Shankar, Vijaykumar,Bandari, Suresh,Murthy, S. Narasimha,Kolter, Karl,Langley, Nigel,Kim, Dong Wuk,Repka, Michael A. Elsevier 2019 International journal of pharmaceutics Vol.554 No.-
<P><B>Abstract</B></P> <P>The objective of this study was to formulate aripiprazole (ARI)-loaded pH-modulated solid dispersions (SD) to enhance solubility, dissolution, and bioavailability via hot-melt extrusion (HME) technology. Kollidon® 12 PF (PVP) and succinic acid (SA) were selected after solubility screenings of various polymers and acidifiers. Several formulations, varying in screw speed and drug/polymer/acidifier ratios, were extruded using an 11 mm twin-screw extruder and were investigated for the effect of these variables. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) were used to perform solid-state characterizations of the pure drug and extrudates. The aqueous solubility and dissolution were evaluated for the pure drug and milled extrudates. Among the prepared formulations, N6 was chosen for <I>in vivo</I> absorption studies. Solid-state characterization demonstrated the transformation of the crystalline ARI to an amorphous state in the formulations. Each formulation showed increased solubility and dissolution compared to the drug powder. The oral bioavailability (C<SUB>max</SUB> and AUC<SUB>0–12</SUB>) of N6 was significantly improved when compared to the pure ARI. This novel study not only discusses the incorporation of acidifiers in SDs but also the preparation of SDs using HME technology as effective techniques to improve drug release and bioavailability.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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