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Kohri, H.,Wang, S. Y.,Shiu, S. H.,Chang, W. C.,Yanai, Y.,Ahn, D. S.,Ahn, J. K.,Chen, J. Y.,Daté,, S.,Ejiri, H.,Fujimura, H.,Fujiwara, M.,Fukui, S.,Gohn, W.,Hicks, K.,Hosaka, A.,Hotta, T.,Hwang, American Physical Society 2018 Physical review. C Vol.97 No.1
<P>Differential cross sections and photon-beam asymmetries for the (gamma) over right arrowp -> pi(+) n reaction have been measured for 0.6 < cos theta(pi) < 1 and E-gamma = 1.5-2.95 GeV at SPring-8/LEPS. The cross sections monotonically decrease as the photon beam energy increases for 0.6 < cos theta(pi) < 0.9. However, the energy dependence of the cross sections for 0.9 < cos theta(pi) < 1 and E-gamma = 1.5-2.2 GeV (W = 1.9-2.2 GeV) is different, which may be due to a nucleon or Delta resonance. The present cross sections agree well with the previous cross sections measured by other groups and show forward peaking, suggesting significant t-channel contributions in this kinematical region. The asymmetries are found to be positive, which can be explained by rho exchange in the t channel. Large positive asymmetries in the small-vertical bar t vertical bar region, where the rho-exchange contribution becomes small, could be explained by introducing p-exchange interference with the s channel.</P>
Kohri, H.,Shiu, S. H.,Chang, W. C.,Yanai, Y.,Ahn, D. S.,Ahn, J. K.,Chen, J. Y.,Daté,, S.,Ejiri, H.,Fujimura, H.,Fujiwara, M.,Fukui, S.,Gohn, W.,Hicks, K.,Hosaka, A.,Hotta, T.,Hwang, S. H.,Imai, American Physical Society 2018 Physical Review Letters Vol.120 No.20
<P>Differential cross sections and photon-beam asymmetries for the gamma(->)p -> Pi(-)Delta(++)(1232) reaction have been measured for 0.7 < cos Theta(c.m.)(Pi) < 1 and E-gamma= 1.5-2.95 GeV at SPring-8/LEPS. The first-ever high statistics cross-section data are obtained in this kinematical region, and the asymmetry data for 1.5 < E-gamma(GeV) < 2.8 are obtained for the first time. This reaction has a unique feature for studying the production mechanisms of a pure uu quark pair in the final state from the proton. Although there is no distinct peak structure in the cross sections, a non-negligible excess over the theoretical predictions is observed at E-gamma= 1.5-1.8 GeV. The asymmetries are found to be negative in most of the present kinematical regions, suggesting the dominance of n exchange in the t channel. The negative asymmetries at forward meson production angles are different from the asymmetries previously measured for the photoproduction reactions producing a dd(-) or an ss quark pair in the final state. Advanced theoretical models introducing nucleon resonances and additional unnatural-parity exchanges are needed to reproduce the present data.</P>
Shiu, S. H.,Kohri, H.,Chang, W. C.,Ahn, D. S.,Ahn, J. K.,Chen, J. Y.,Daté,, S.,Ejiri, H.,Fujimura, H.,Fujiwara, M.,Fukui, S.,Gohn, W.,Hicks, K.,Hotta, T.,Hwang, S. H.,Imai, K.,Ishikawa, T.,Joo, American Physical Society 2018 Physical Review C Vol.97 No.1
<P>We report the measurement of the gamma p -> K+Lambda and gamma p -> K+Sigma(0) reactions at SPring-8. The differential cross sections and photon-beam asymmetries are measured at forward K+ production angles using linearly polarized tagged-photon beams in the range of E-gamma = 1.5-3.0 GeV. With increasing photon energy, the cross sections for both gamma p -> K+Lambda and gamma p -> K+Sigma(0) reactions decrease slowly. Distinct narrow structures in the production cross section have not been found at E gamma = 1.5-3.0 GeV. The forward peaking in the angular distributions of cross sections, a characteristic feature of t-channel exchange, is observed for the production of Lambda in the whole observed energy range. A lack of similar feature for Sigma(0) production reflects a less dominant role of t-channel contribution in this channel. The photon-beam asymmetries remain positive for both reactions, suggesting the dominance of K* exchange in the t channel. These asymmetries increase gradually with the photon energy, and have a maximum value of +0.6 for both reactions. Comparison with theoretical predictions based on the Regge trajectory in the t channel and the contributions of nucleon resonances indicates the major role of t-channel contributions as well as non-negligible effects of nucleon resonances in accounting for the reaction mechanism of hyperon photoproduction in this photon energy regime.</P>
Akita, Hidetoshi,Nakane, Akihiro,Ando, Ryosuke,Yamada, Kenji,Kobayashi, Takahiro,Okamura, Takehiko,Kohri, Kejiro Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: While 5-port laparoendoscopic radical prostatectomy is standard practice, efforts have been focused in developing a single port surgery for cosmetic reasons. However, this is still in the pioneering stage considering the challenging nature of the surgical procedures. We have therefore focused on reduced port surgery, using only 2-ports. In this study, we compared 2-port laparoendoscopic radical prostatectomy (2-port RP) and conventional 5-port laparoscopic radical prostatectomy (LRP) for clinically localized prostate carcinoma and evaluated the potential advantages of each. Materials and Methods: From January 2010 to December 2010, all 23 patients with clinically localized prostate cancer underwent LRP. Starting November, 2010, when we introduced the reduced port approach, we performed this procedure for 22 consecutive patients diagnosed with early-stage prostate cancer (cT1c, cT2N0). The patients were matched 1:1 to 2-port RP or LRP for age, preoperative serum PSA level, clinical stage, biopsy and pathological Gleason grade, surgical margin status, pad-free rates and post-operative pain. Results: There was a significant difference in operative time between the 2-port RP and LRP groups ($286.5{\pm}63.3$ and $351.8{\pm}72.4$ min: p=0.0019, without any variation in blood loss (including urine) ($945.1{\pm}479.6$ vs $1271.1{\pm}871.8ml$: p=0.13). The Foley catheter indwelling period was shorter in the 2 port RP group, but without significance ($5.6{\pm}1.8$ vs $8.0{\pm}5.6$ days: p=0.057) and the total perioperative complication rates for 2 port RP and LRP were comparable at 4.5% and 8.7% (p=0.58). There was an improvement in pad-free rates up to 6 months follow-up (p=0.090), and significantly improvement at 1 year (p=0.040). PSA recurrence was 1 (4.5%) in 2-port RP and 2 (8.7%) in LRP. Continuous epidural anesthesia was used in most of LRP patients (95.7%) and in early 2-port RP patients (40.9%). In these patients, average total amount of Diclofenac sodium was 27.8mg/patient in 2-port RP and 50.0mg/patient in LRP. Conclusions: Thus the reduced port approach is as efficacious as LRP in terms of many outcome measures, with significant cosmetic advantages and reduction in post surgical pain. This method can be readily performed safely and therefore can be recommended as a standard laparoscopic surgery for prostate cancer in the future.
Kubota, Hiroki,Taguchi, Kazumi,Kobayashi, Daichi,Naruyama, Hiromichi,Hirose, Masahito,Fukuta, Katsuhiro,Kubota, Yasue,Yasui, Takahiro,Yamada, Yasuyuki,Kohri, Kenjiro Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Malignant bowel obstruction (MBO), an occasional complication in patients with advanced urological cancer, causes gastrointestinal symptoms such as nausea and vomiting leading to suffering which severely impairs quality of life (QOL). Drug therapy, especially octreotide, a synthetic analog of somatostatin, is reportedly effective in controlling the symptoms of MBO. In the present study, we administered octreotide to urological cancer patients with MBO and evaluated the improvement of subjective symptoms, oral intake, and nasogastric intubation. Fourteen terminally ill urological cancer patients suffering with MBO were included (age range 55-92, 10 male, 4 female). Octreotide was administered at $300{\mu}g/day$ to those patients subcutaneously as a continuous injection. Significant improvements in subjective symptoms were observed in thirteen patients (92.8%), and ten patients (71.4%) were able to resume oral intake. Four patients required nasogastric drainage before the administration of octreotide, but nasogastric intubation was discontinued in all these cases after the use of octreotide. Early initiation of octreotide resulted in better improvement of MBO symptoms, and no adverse event was observed in any of the patients. These results revealed that $300{\mu}g/day$ dose of octreotide is safe and effective for managing gastrointestinal symptoms of terminally ill urological cancer patients with MBO. We also recommend starting the treatment with ocreotide as soon as MBO is diagnosed.
Okamura, Takehiko,Ando, Ryosuke,Akita, Hidetoshi,Hashimoto, Yoshihiro,Iwase, Yutaka,Naiki, Taku,Kawai, Noriyasu,Tozawa, Keiichi,Kohri, Kenjiro Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Objective: The guidelines on indications for prophylactic use of Bacille Calmette-Gu$\acute{e}$rin (BCG) against non-muscle-invasive bladder cancer (NMIBC) have changed over the years. In order to assess the impact on outcome, the present retrospective comparison of BCG efficacy by time period with Japanese patients was conducted. Patients and Methods: A total of 146 cases of NMIBC treated with BCG since February 1985 were retrospectively evaluated. All patients received 80 mg of BCG (Tokyo 172 strain) six to eight times a week for prophylactic use. Comparison was made among three historical groups (Group A: 1980's, 39 cases; Group B: 1990's, 61 cases; Group C: 2000's, 46 cases). Results: In total, recurrence was seen in 55 of the 146 cases (37.7%), and progression in 14 (9.6%), 1 patient dying of cancer. These overall results were similar to those outlined in previous reports. However, the outcomes of this time-period-based analysis indicated a tendency for a shorter time to recurrence in patients after 2000, although a log-rank test showed no significance (P=0.229). Seven of the cases featuring progression (i.e., half of all such cases) were among the 46 Group C patients (15.2%). Excluding these progressive cases, there was no significant difference among the remaining 132 patients in the three groups. Conclusion: This study results revealed a tendency for a lower non-recurrence rate after 2000 in our series. This could stem from a number of factors, including changes in BCG indication criteria and the evolution of histopathological diagnostic criteria.