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- 저자 : Kohei Honda (검색결과 2 건)
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Performance Evaluations of PC Clusters for Large Scale Numerical Analyses
Kohei Honda,Tatsuya Furukawa,Hisao Fukumoto,Masashi Ohchi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
The PC cluster is a system that is connected two or more PC on the network and uses them as one parallel computer. Conventional numerical analyses can be executed comparatively low?ost by using PC cluster. In the authors’ laboratory, the PC cluster has been constructed. The author has made a finite element analysis parallel program and evaluated it. However, there is a possibility that the performance of the PC cluster will depend on clustering software. In addition, it has become able to build a higher?erformance cluster more cheaply by the rapid progress of hardware performance. Therefore the authors have constructed the PC cluster newly using two kinds of clustering software on Windows and Linux and compared both of them. Ten PCs which equipped dual core CPU were used for PC cluster. The HPL benchmark test for the present cluster system has been conducted to evaluate the performance. As a result, the processing speed has not improved in Windows but it has improved well in Linux.
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Kohei Suzuyama,Makoto Eriguchi,Hiromu Minagawa,Hiroyuki Honda,Keita Kai,Tetsuyuki Kitamoto,Hideo Hara 대한신경과학회 2024 Journal of Clinical Neurology Vol.20 No.3
Background and Purpose The coast of Kyushu Island on Ariake Sea in Japan is known to be an accumulation area for patients with a proline-to-leucine substitution mutation at residue 102 (P102L) of the human prion protein gene (PRNP), which is associated with Gerstmann– Sträussler–Scheinker disease. We designated this geographical distribution as the “Ariake PRNP P102L variant.” The purpose of this study was to characterize the clinical features of this variant. Methods We enrolled patients with the PRNP P102L variant who were followed up at the Saga University Hospital from April 2002 to November 2019. The clinical information of patients were obtained from medical records, including clinical histories, brain magnetic resonance imaging (MRI), and electroencephalography (EEG). A brain autopsy was performed on one of the participants. Results We enrolled 24 patients from 19 family lines, including 12 males. The mean age at symptom onset was 60.6 years (range, 41–77 years). The incidence rate of the Ariake PRNP P102L variant was 3.32/1,000,000 people per year in Saga city. The initial symptoms were ataxia (ataxic gait or dysarthria) in 19 patients (79.2%), cognitive impairment in 3 (12.5%), and leg paresthesia in 2 (8.3%). The median survival time from symptom onset among the 18 fatal cases was 63 months (range, 23–105 months). Brain MRI revealed no localized cerebellar atrophy, but sparse diffusion-weighted imaging abnormalities were detected in 16.7% of the patients. No periodic sharp-wave complexes were identified in EEG. Neuropathological investigations revealed uni- and multicentric prion protein (PrP) plaques in the cerebral cortex, putamen, thalamus, and cerebellum of one patient. Western blot analysis revealed 8-kDa proteinase-Kresistant PrP. Conclusions This is the first report of the accumulation area of a PRNP P102L variant on the coast of Ariake Sea. The Ariake PRNP P102L variant can be characterized by a relatively long disease duration with sparse abnormalities in brain MRI and EEG relative to previous reports. Detailed interviews to obtain information on the birthplace and the family history of related symptoms are important to diagnosing a PRNP P102L variant.
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