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RISS 인기검색어
- 검색키워드
- 저자 : Klaus W.J. Wahle (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Effects of Conjugated Linoleic Acid on Adipocyte Secreted Proteins in vitro
Jung-Heun Ha,In-Sook Ahn,Jae-Min Byun,Hyung Ki Do,Sun-Young Jung,Jae-Hong Jeong,Klaus W.J. Wahle,Kun-Young Park,Myoung-Sool Do 한국식품영양과학회 2003 Preventive Nutrition and Food Science Vol.8 No.3
Conjugated linoleic acid (CLA) is a class of positional, geometric conjugated dienoic isomers of linoleic acid (LA). CLA activates the immune system, protects against tumorigenesis, and reduces the incidence of atherosclerosis. Trans-10, cis-12 CLA has specific effects on lipid metabolism, it has been shown to reduce body fat gain and regulates some adipocyte secreted proteins in vivo and in vitro. Here we report that a CLA mixture affects cytokine secretion from rat primary adipocytes. Rat primary adipocytes were treated with 1 mM, 100 μM, 1 μM or 100 nM CLA mixture doses; and leptin, tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6) and glycerol levels in the medium were measured. Leptin secretion was lower, TNFα secretion higher and IL-6 secretion did not change in response to the CLA mixture. Leptin and TNFα secretions did not change with CLA mixture treatment in a dose-dependent manner. In addition, the CLA mixture did not appear to enhance lipolysis in rat primary adipocytes. In conclusion, our study demonstrates that the decrease in leptin and increase in TNFα secretion in adipocytes treated with CLA mixture may be due to the apoptotic effect and to a reduction in peroxisome proliferator-activated receptor gamma (PPARγ) ligands.
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Effects of Conjugated Linoleic Acid on Adipocyte Secreted Proteins in vitro
Ha, Jung-Heun,Ahn, In-Sook,Byun, Jae-Min,Do, Hyung-Ki,Jung, Sun-Young,Jeong, Jae-Hong,Wahle, Klaus W.J.,Park, Kun-Young,Do, Myoung-Sool The Korean Society of Food Science and Nutrition 2003 Preventive Nutrition and Food Science Vol.8 No.3
Conjugated linoleic acid (CLA) is a class of positional, geometric conjugated dienoic isomers of linoleic acid (LA). CLA activates the immune system, protects against tumorigenesis, and reduces the incidence of atherosclerosis. Trans-10, cis-12 CLA has specific effects on lipid metabolism, it has been shown to reduce body fat gain and regulates some adipocyte secreted proteins in vivo and in vitro. Here we report that a CLA mixture affects cytokine secretion from rat primary adipocytes. Rat primary adipocytes were treated with 1 mM, 100 $\mu$M, 1 $\mu$M or 100 nM CLA mixture doses; and leptin, tumor necrosis factor alpha (TNF a ), interleukin-6 (IL-6) and glycerol levels in the medium were measured. Leptin secretion was lower, TNF $\alpha$ secretion higher and IL-6 secretion did not change in response to the CLA mixture. Leptin and TNF $\alpha$ secretions did not change with CLA mixture treatment in a dose-dependent manner. In addition, the CLA mixture did not appear to enhance lipolysis in rat primary adipocytes. In conclusion, our study demonstrates that the decrease in leptin and increase in TNF $\alpha$ secretion in adipocytes treated with CLA mixture may be due to the apoptotic effect and to a reduction in peroxisome proliferator-activated receptor gamma (PPAR ${\gamma}$ ) ligands.
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