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- 저자 : Kazumasa Yamamoto (검색결과 2 건)
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Effects of Aloe-emodin and Emodin on Proliferation of the MKN45 Human Gastric Cancer Cell Line
Chihara, Takeshi,Shimpo, Kan,Beppu, Hidehiko,Yamamoto, Naoki,Kaneko, Takaaki,Wakamatsu, Kazumasa,Sonoda, Shigeru Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Aloe-emodin (1, 8-dihydroxy-3-hydroxyl-methylanthraquinone; AE) and emodin (1,3,8-trihydroxy-6-methylanthraquinone; EM) are anthraquinone derivatives that have been detected in some medical plants and share similar anthraquinone structures. AE and EM have been shown to exhibit anticancer activities in various cancer cell lines; however, the inhibitory effects of these derivatives on the growth of cancer cells were previously reported to be different. Gastric cancer is the second most common cause of cancer cell death worldwide. In the present study, we examined the inhibitory effects of 0.05 mM AE and 0.05 mM EM on the proliferation of the MKN45 human gastric cancer cell line. The proliferation of MKN45 cells was significantly inhibited in AE- and EM-treated groups 24 h and 48 h after treatment. Furthermore, the inhibitory effects of EM were stronger than those of AE. The cell cycle of MKN45 cells were arrested in G0/G1 phase or G0/G1 and G2/M phases by AE and EM, respectively. However, an analysis of intracellular polyamine levels and DNA fragmentation revealed that the mechanisms underlying cell death following cell arrest induced by AE and EM differed.
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Numerical Study of Slow-wave Instabilities in an Oversized Coaxial Slow-wave Structure
Kazuo Ogura,Shingo Abe,Hiroki Kimura,Kazumasa Yamamoto,Kiyoyuki Yambe,Ruhul Amin 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
In this paper, slow-wave instabilities in oversized coaxial SWSs are numerically analyzed. An infinitesimally thin annular beam with transverse perturbations and guided by a finite axial magnetic field is considered as the energy source for creating the instabilities. The coaxial SWSs consist of an outer oversized hollow waveguide and a central conductor and have sinusoidal corrugations. An electromagnetic slow-wave is generated by the inner corrugation and is called inner surface wave (ISW). The ISW is a cylindrical surface wave and can exist even if the outer conductor is removed. The higher-order modes are produced by the outer waveguide. The annular beam interacts with the ISW and higher-order modes. Slow cyclotron instability occurs due to the transversely modulated beam boundary, in addition to the conventional Cherenkov instability. The slow-wave instabilities are able to be controlled by the beam radius and the relative position of inner and outer corrugations.
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