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RISS 인기검색어
- 검색키워드
- 저자 : Kanagavalli, K. (검색결과 2 건)
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Rajendran Rajaram,Pandiyaraj Kanagavalli,Shanmugam Senthilkumar,Jayaraman Mathiyarasu 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.5
Glutathione (GSH) is an important bio-thiol which is playing vital role in the human system, such as treating glaucoma, preventing asthma, cancer, etc. Therefore, electrochemical sensing of GSH is becoming very vital to know the level of the biomolecule in living systems. Hence, the present work aims to develop a sensor matrix for electrochemical biosensing of GSH at Au nanoparticle decorated Nanoporous poly(3,4)ethylene dioxythiophene (PEDOT) modified glassy carbon electrode (AuNPPEDOT/ GCE). The electrode is modified with a nanoporous fibrillar network of PEDOT containing Au nanoparticles and characterized using UV-Visible spectroscopy and Field Emission Scanning Electron Microscopy (FESEM). The platform is capable of producing enhanced signal against the bio-analyte at the applied overpotential of 0.6 V. Whereas bare glassy carbon electrode is unable to produce the signal. Conversely, Nanoporous PEDOT modified glassy carbon electrode can sense GSH of very low sensitivity at an applied overpotential of 0.7 V. From single step chronoamperometric measurements, kinetic parameters such as diffusion coefficient and apparent rate constant of the reaction were found as 5.01 × 10-5 cm2·s-1 and 1.106 × 103 M-1·s-1 respectively. From the amperometric response, the sensitivity and limit of detection (LOD) of the electrode were to be 10.7 μA cm-2/μM and 0.173 μM respectively with the linear range of 0.5 to 10 μM. The matrix can detect GSH in the presence of other possible interfering molecules present in blood samples.
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Rajalakshmi, S.,Samraj, K.,Sathiyarajeswaran, P.,Kanagavalli, K. Cellmed Orthocellular Medicine and Pharmaceutical 2020 셀메드 (CellMed) Vol.10 No.4
COVID-19 (Corona Virus Disease-2019) is an infectious respiratory disease caused by the most recently discovered coronavirus, SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona virus-2). This new viral disease was unknown before the outbreak began in Wuhan, China, in December 2019. As of November 16th 2020, it affects about 54.3 million populations, death troll increased to 1.32 million cases in worldwide. Whereas in India 8.85 cases are infected with COVID-19, of which 1, 30, 112 cases were died. Till now there has been no specific anti-virus drug or vaccines are available for the treatment of this disease, the supportive care and non-specific treatment to the symptoms of the patient are the only options in Biomedicine, the entire world turns its attention towards alternative medicine or Traditional medicine. Siddha medicine is one of the primordial systems of medicine practiced in the southern part of India, it dealt a lot about pandemic, and its management. This review provides an insight into Pandemic in Siddha system and its management in both ancient history and modern history, National and state level Government policies related to current pandemic, World Health Organization (WHO) guidelines on usage of unproven drug during infectious disease outbreak, Preparedness of Siddha system during a pandemic outbreak Challenges and Recommendations.
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