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RISS 인기검색어
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- 저자 : K.N. Lokesh (검색결과 2 건)
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Murali G,Venkatesh J.,Lokesh N.,Nava Teja Reddy,Karthikeyan K. 대한토목학회 2018 KSCE Journal of Civil Engineering Vol.22 No.8
This study examines the impact energy dissipation capacity of Ultra High Performance Fibre Reinforced Concrete (UHPFRC). Forthis purpose, nine different mixes were fabricated with hooked end and crimped steel fibres at a dosage of 0.5, 1.0, 1.5 and 2.0percentage and tested under pendulum impact test. The impact energy dissipation capacity is assessed based on test (Charpy U-notch)procedure suggested by ASTM E23. Also, an analytical model was adopted to predict the impact energy dissipation value ofUHPFRC and its performance is verified against experimental results. Based on the test results, the impact energy dissipationcapacity of the mixtures containing crimped and hooked end steel fibres were significantly higher than that of Plain Concrete (PC). The hooked end steel fibres had an increased impact energy dissipation capacity compared to crimped steel fibres, which implies thathooked end steel fibre is more appropriate for enhancing the impact energy dissipation of UHPFRC. Also, the modelling datacompared well with experimental data for the fibre volume fraction beyond 0.5%.
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HIV/AIDS-related lymphoma: perspective from a regional cancer center in India
A.H. Rudresha,Pravin Ashok Khandare,D. Lokanatha,Abraham Jacob Linu,M.C. Suresh Babu,K.N. Lokesh,L.K. Rajeev,Carol Saldanha Smitha,Vaibhav Baburao Amale,C.S. Premalata,Mulchandani Nikita 대한혈액학회 2019 Blood Research Vol.54 No.3
BackgroundIndia has the third largest population of people living with HIV/AIDS (PLHA). Lymphoma is the second most common malignancy among PLHA. However, data are lacking regard-ing HIV/AIDS-related lymphoma (ARL) in India. This study evaluated the epidemiology and clinical outcomes of ARL from a regional cancer center in India.MethodsThis retrospective analysis included cases of ARL between March 2011 and September 2017. Data were obtained from patient record files for the assessment of epidemiology and clinical outcomes. Statistical analysis was performed using GraphPad Prism 6. Comparisons of subtype-specific survivals were performed using log-rank tests.ResultsOf 1,226 lymphoma cases, 80 (6.5%) were ARL. Details were available for 70 patients. The median age at diagnosis was 40.5 (9‒74) years with a male:female ratio of 2:1. AIDS-defining lymphomas (ADL) constituted 78.6% of cases, while 21.4% had non-AIDS defining lymphoma (NADL). The mean CD4 counts were 193.15±92.85 and 301.93±107.95 cells/L, respectively (t-test; P=0.0002). Extranodal involvement was present in 55.7%, B symptoms were reported in 60%, and lactate dehydrogenase (LDH) was elevated in 64.3% of patients. The median overall survival times were 6 months for plasmablastic lymphoma (PBL), 23 months for diffuse large B-cell lymphoma (DLBCL), and was not reached for Hodgkin’s lymphoma (log-rank test; P=0.0011). Other histo-logical subtype cases were too few to draw meaningful survival outcomes.ConclusionARL is a heterogeneous disease. Histologic subtype is a major determinant of the clinical outcome. ADL has significantly lower CD4 counts than those of NADL. There is an urgent and unmet need for uniform management guidelines for improving outcomes in this un-der-represented patient population.
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