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Bakht, Mohamadreza K.,Sadeghi, Mahdi,Ahmadi, Seyed J.,Sadjadi, Sodeh S.,Tenreiro, Claudio Lippincott Williams Wilkins, Inc. 2013 Nuclear medicine communications Vol.34 No.1
OBJECTIVE: Many studies have attempted to assess the significance of the use of the &bgr;-particle emitter praseodymium-142 (Pr) in cancer treatment. As praseodymium oxide (Pr2O3) powder is not water soluble, it was dissolved in HCl solution and the resultant solution had to be pH adjusted to be in an injectable radiopharmaceutical form. Moreover, it was shown that the nanosized neodymium oxide (Nd2O3) induced massive vacuolization and cell death in non-small-cell lung cancer. In this work, the production of Pr was studied and water-dispersible nanosized Pr2O3 was proposed to improve the application of Pr in nuclear medicine. MATERIALS AND METHODS: Data from different databases pertaining to the production of Pr were compared to evaluate the accuracy of the theoretical calculations. Water-dispersible nanosized Pr2O3 was prepared using a poly(ethylene glycol) (PEG) coating or PEGylation method as a successful mode of drug delivery. Radioactive Pr2O3 was produced via a Pr(n,&ggr;)Pr reaction by thermal neutron bombardment of the prepared sample. RESULTS: There was good agreement between the reported experimental data and the data based on nuclear model calculations. In addition, a small part of nano-Pr2O3 particles remained in suspension and most of them settled out of the water. Interestingly, the PEGylated Pr2O3 nanoparticles were water dispersible. After neutron bombardment of the sample, a stable colloidal Pr2O3 was formed. CONCLUSION: The radioactive Pr2O3 decays to the stable Nd2O3. The suggested colloidal Pr2O3 as a multifunctional therapeutic agent could have dual roles in cancer treatment as a radiotherapeutic agent using nanosized Pr2O3 and as an autophagy-inducing agent using nanosized Nd2O3.
Z. Poursharifi,H. Asadi,K. Sadeghy 한국유변학회 2018 Korea-Australia rheology journal Vol.30 No.2
We have numerically studied the effect of a fluid’s yield stress on the performance of a peristaltic mixer reinforced by cylindrical pillars, typical of those used in microfluidic systems. A multiple-relaxation-time, Lattice Boltzmann code was used to investigate the effect of a fluid’s yield stress on mixing efficiency for a viscoplastic fluid obeying the bi-viscous model. A Lagrangian particle-tracking method called “boxcounting” has been utilized for evaluating the mixing performance of the channel through introducing a stirring index parameter. Numerical results indicate that for both Newtonian and Bingham fluids, wave amplitude is the most potent tool for controlling the mixing performance of the mixer. It is shown that while for Newtonian fluids the mixing index is dropped if the channel is equipped with circular pillars, for Bingham fluids pillars can play a slightly positive role in enhancing the mixing efficiency of the mixer, and this is particularly so when the confinement ratio is sufficiently large. A more dramatic increase in the mixing efficiency can be attained when only one of the membranes is vibrating (i.e., the asymmetric case).
Peristaltic transport of thixotropic fluids: A numerical simulation
S.M.J. Sobhani,N.P. Khabazi,S. Bazargan,P. Sadeghi,K. Sadeghy 한국유변학회 2019 Korea-Australia rheology journal Vol.31 No.2
Peristaltic flow of a thixotropic fluid obeying the Moore model is numerically studied using the multiplerelaxation-time lattice Boltzmann method (MRT-LBM). Converged results could be obtained in a planar two-dimensional channel at large Reynolds numbers for arbitrary wavelengths and amplitude ratios for nonzero Reynolds numbers. It is shown that depending on the Reynolds number and the parameters of the propagating wave, the time constant introduced through a fluid’s thixotropy may increase the mean flow rate of peristaltic pumps. Our numerical results suggest that for thixotropic fluids there exists a threshold wavenumber for the peristaltic wave above which thixotropy can boost fluid transport but below which it can have an opposite effect.
Low-Frequency Acoustic Phonon Temperature Distribution in Electrically Biased Graphene
Jo, Insun,Hsu, I-Kai,Lee, Yong J.,Sadeghi, Mir Mohammad,Kim, Seyoung,Cronin, Stephen,Tutuc, Emanuel,Banerjee, Sanjay K.,Yao, Zhen,Shi, Li American Chemical Society 2011 Nano letters Vol.11 No.1
<P>On the basis of scanning thermal microscopy (SThM) measurements in contact and lift modes, the low-frequency acoustic phonon temperature in electrically biased, 6.7−9.7 μm long graphene channels is found to be in equilibrium with the anharmonic scattering temperature determined from the Raman 2D peak position. With ∼100 nm scale spatial resolution, the SThM reveals the shifting of local hot spots corresponding to low-carrier concentration regions with the bias and gate voltages in these much shorter samples than those exhibiting similar behaviors in the infrared emission maps.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2011/nalefd.2011.11.issue-1/nl102858c/production/images/medium/nl-2010-02858c_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl102858c'>ACS Electronic Supporting Info</A></P>