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RISS 인기검색어
- 검색키워드
- 저자 : Jude E. Okokon (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Okokon, Jude E.,Ekpo, Arit J.,Eseyin, Olorunfemi A. The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
The leaves and seeds of Telfairia occidentalis are used as vegetables in making soups in Southern Nigeria. In this study, we investigated the antimalarial activity of leaf and seed extracts in vivo in mice infected with Plasmodium berghei berghei during early and established infections. T. occidentalis leaf extract (250-750 mg/kg/day) exhibited antiplasmodial activity both in the 4-day early infection test and in established infection with a marked increase of the mean survival time, which, however, remained lower than that achieved with the standard drug, chloroquine (5 mg/kg/day). The seed extract (450-1,350 mg/kg/day) also demonstrated a promising blood schizontocidal activity in early and established infections. This plant possesses significant antiplasmodial activities, which may be exploited in the control of malaria.
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Antiplasmodial and Antidiabetic Activities of Ethanolic Leaf Extract of Heinsia crinata
Okokon, Jude E.,Umoh, Emem E.,Etim, Emmanuel I.,Jackson, Clement L. The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1
The ethanolic leaf extract of Heinsia crinata, grown particularly for the leaf in Niger Delta region of Nigeria, was evaluated for antiplasmodial activity in Plasmodium berghei-infected mice as well as for hypoglycemic and antidiabetic activities in alloxan-induced diabetic rats. H. crinata (450-1,350 mg/kg/day) exhibited significant (P < .05) blood schizonticidal activity in both the 4-day early infection test and established infection with a considerable mean survival time, though not comparable to that of the standard drug, chloroquine (5 mg/kg/day). Treatment of alloxan-induced diabetic rats with the leaf extract caused a significant (P < .01) reduction in fasting blood glucose levels of normal and alloxan-induced diabetic rats both in an acute study and with prolonged treatment (2 weeks). The activity of the extract was comparable to that of the reference drug, glibenclamide, during the acute study but was not comparable to that of the standard drug during prolonged treatment. The results suggest that the leaf extract of H. crinata possesses significant (P < .05) antiplasmodial as well as hypoglycemic and antidiabetic effects that can be employed in health care.
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Antiplasmodial and Antidiabetic Activities of Ethanolic Leaf Extract of Heinsia crinata
Jude E. Okokon,Emem E. Umoh,Emmanuel I. Etim,Clement L. Jackson 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.1
The ethanolic leaf extract of Heinsia crinata, grown particularly for the leaf in Niger Delta region of Nigeria, was evaluated for antiplasmodial activity in Plasmodium berghei-infected mice as well as for hypoglycemic and antidiabetic activities in alloxan-induced diabetic rats. H. crinata (450–1,350 mg/kg/day) exhibited significant (P < .05) blood schizonticidal activity in both the 4-day early infection test and established infection with a considerable mean survival time, though not comparable to that of the standard drug, chloroquine (5 mg/kg/day). Treatment of alloxan-induced diabetic rats with the leaf extract caused a significant (P < .01) reduction in fasting blood glucose levels of normal and alloxan-induced diabetic rats both in an acute study and with prolonged treatment (2 weeks). The activity of the extract was comparable to that of the reference drug, glibenclamide, during the acute study but was not comparable to that of the standard drug during prolonged treatment. The results suggest that the leaf extract of H. crinata possesses significant (P < .05) antiplasmodial as well as hypoglycemic and antidiabetic effects that can be employed in health care.
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Jude E. Okokon,Arit J. Ekpo,Olorunfemi A. Eseyin 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
The leaves and seeds of Telfairia occidentalis are used as vegetables in making soups in Southern Nigeria. In this study, we investigated the antimalarial activity of leaf and seed extracts in vivo in mice infected with Plasmodium berghei berghei during early and established infections. T. occidentalis leaf extract (250–750mg/kg/day) exhibited antiplasmodial activity both in the 4-day early infection test and in established infection with a marked increase of the mean survival time, which, however, remained lower than that achieved with the standard drug, chloroquine (5mg/kg/day). The seed extract (450–1,350mg/kg/day) also demonstrated a promising blood schizontocidal activity in early and established infections. This plant possesses significant antiplasmodial activities, which may be exploited in the control of malaria.
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