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Nonparametric testing under crossover design for ordered categorical response
Joydeep Basu,Uttam Bandyopadhyay,Ganesh Dutta 한국통계학회 2017 Journal of the Korean Statistical Society Vol.46 No.4
This paper uses ridit introduced by Bross (1958) to develop a nonparametric procedure for testing the difference between two treatment effects with ordered categorical outcomes under two period crossover design in which subjects receive same or different treatment during the period of study. The performance of this procedure is compared numerically with that of a procedure obtained from Armitage (1955) in terms of type I error rate and power. The numerical study shows the ridit approach to tend to relatively more efficient in terms of power as the number of categories increases. The procedures are illustrated using the data from Matthews (1989) on crossover trial with two hypertensive agents.
Basu, Kaustuv,Mukherjee, Joydeep,Law, Sujata,Chaudhuri, Samaresh Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Biological response modifiers (BRMs) can alter interactions between the immune system and cancer cells to boost, direct, or restore the body's ability to fight disease. Mice with ethylnitrosourea- (ENU) induced leukemia were here used to monitor the therapeutic efficacy of lipopolysaccaride (LPS), Bacillus Calmette Guerin (BCG) and sheep erythrocytes (SRBC). Flow cytometry based CD34+ positivity analysis, clonogenicity, proliferation and ultrastructure studies using scanning electron microscopy (SEM) of stem cells in ENU induced animals with and without BRMs treatment were performed. BRMs improved the stem-stromal relationship structurally and functionally and might have potential for use as an adjunct in human stem cell therapy.
Chattopadhyaya, Banani,Banerjee, Joydeep,Basu, Asitava,Sen, Soumitra K.,Maiti, Mrinal K. The Korean Society of Plant Biotechnology 2010 Plant biotechnology reports Vol.4 No.2
An efficient protocol for shoot regeneration was developed for sesame (Sesamum indicum L.) internodes using the transverse thin cell layer (tTCL) culture method. The frequency of shoot regeneration and the number of adventitious buds produced from regenerated shoots depend significantly on explant age, thickness of the tTCL sections, and the phytohormones supplemented to the culture medium. A combination of 6-benzyladenine (2.0 $mg\;l^{-1}$) and a-naphthaleneacetic acid (0.5 $mg\;l^{-1}$) was found to be the best phytohormone combination for shoot bud induction, with the maximum number of shoots obtained when the tTCL sections were 0.5-1.0 mm thick and derived from 4- to 6-week-old seedlings of sesame. Well-developed shoots were rooted on MS medium without phytohormones, and 80% of the regenerated plantlets were successfully established in soil.