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In Vitro Susceptibility of Mycobacterium tuberculosis Clinical Isolates to Garenoxacin and DA-7867
Vera-Cabrera, Lucio,Castro-Garza, Jorge,Rendon, Adrian,Ocampo-Candiani, Jorge,Welsh, Oliverio,Choi, Sung Hak,Blackwood, Kym,Molina-Torres, Carmen American Society for Microbiology 2005 Antimicrobial agents and chemotherapy Vol.49 No.10
<B>ABSTRACT</B><P>The in vitro activities of DA-7867, a novel oxazolidinone, and garenoxacin (BMS-284756) were compared to those of linezolid in 67 susceptible and drug-resistant clinical isolates of <I>Mycobacterium tuberculosis</I>. DA-7867 was the most active drug with an MIC90 of 0.125 μg/ml, compared to the MIC90s of 4 μg/ml of garenoxacin and 2 μg/ml of linezolid.</P>
Vera-Cabrera, Lucio,Gonzalez, Eva,Rendon, Adrian,Ocampo-Candiani, Jorge,Welsh, Oliverio,Velazquez-Moreno, Victor M.,Hak Choi, Sung,Molina-Torres, Carmen American Society for Microbiology 2006 Antimicrobial agents and chemotherapy Vol.50 No.9
<B>ABSTRACT</B><P>The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of <I>Nocardia brasiliensis</I> and <I>Mycobacterium tuberculosis</I> were determined. Equal MIC50s and MIC90s (0.25 and 0.5 μg/ml, respectively) were found for susceptible and multidrug-resistant isolates of <I>M. tuberculosis</I>. The <I>N. brasiliensis</I> isolates showed an MIC90 of 1 μg/ml and an MIC50 of 1 μg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for <I>M. tuberculosis</I> but fivefold-higher MICs for <I>N. brasiliensis</I>.</P>
Alejandro Hernández-Morales,Jackeline Lizzeta Arvizu-Gómez,Candy Carranza-Álvarez,Blanca Estela Gómez-Luna,Brenda Alvarado-Sánchez,Enrique Ramírez-Chávez,Jorge Molina-Torres 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.2
Heliopsis longipes has been recognized as a potential source of insecticidal compounds called alkamides, which can be used to control populations of insect vector transmitters of several diseases that affect the human health. To determine the insecticidal activity of H. longipes against Anopheles albimanus and Aedes aegypti, crude extract of H. longipes roots and affininwere obtained. Catalytic reduction of affininwas performed to obtain two reduced amides, N-isobutil-2E-decenamide and N-isobutil-decanamide. Crude extract, affinin and its reduced amides were evaluated against third instar larvae of An. albimanus and Ae. aegypti. Results show that crude extract of H. longipes possess larvicidal activity against larval stage of An. albimanus and Ae. aegypti. This effect could be attributed to affinin, on which the conjugated double bonds present in the structure of the molecule are necessary to maintain larvicidal activity. This study demonstrated the potential of H. longipes to control larval stage of An. albimanus and Ae. aegypti, transmitter vectors of malaria and dengue fever, respectively.