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- 저자 : Jia Wei Chew (검색결과 2 건)
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Henry J. Tanudjaja,Angie Qi Qi Ng,Jia Wei Chew 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.106 No.-
Membrane fouling by the high protein concentrations used in the biopharmaceutical industry remainspoorly understood. In this study, feed concentrations of up to 10,000 ppm of bovine serum albumin(BSA) were investigated with three polymeric membranes, two of which had the same molecular weightcut-off (namely, PES100 and PSF100), and two were of the same membrane material (namely, PES100 andPES10). A crossflow ultrafiltration (UF) setup equipped with electrical impedance spectroscopy (EIS) wasused. Results indicate that fouling was predominantly external for all cases, except for the PES100 membrane(i.e., most porous) at 10,000 ppm of BSA, whereby fouling was internal which led to the greatestflux decline. For 10,000 ppm of BSA, (i) for the PES100 and PSF100 membranes, the Nyquist plots shiftedto the left initially, then to the right as the BSA deposition started, but (ii) for the tighter PES10 membrane,the shifts kept going leftwards due to NaCl accumulation out-pacing BSA build-up. The main takeawayfor filtering feeds with high BSA concentrations is that higher steady-state flux could be achieved byaverting internal fouling, either through using membranes with dense internal structures or lowerMWCO.
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Membrane fouling mechanisms by BSA in aqueous-organic solvent mixtures
Melike Begum Tanis-Kanbur,Navin Raj Tamilselvam,Jia Wei Chew 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
To exploit the benefits of membrane-based separation for the pharmaceutical and chemical industries,the understanding of membrane fouling in organic solvents is crucial. Specifically for the separation ofbiocatalysts in the manufacture of pharmaceuticals, this study investigated membrane fouling by bovineserum albumin (BSA) in 10% v/v isopropanol (IPA), 10% v/v dimethyl sulfoxide (DMSO), 30% v/v IPA, and30% v/v DMSO, benchmarked against that in water. The presence of either IPA or DMSO worsened fouling,with the latter comparatively worse. To understand the fouling mechanisms, Field Emission ScanningElectron Microscopy (FESEM) images were taken to assess external fouling, Evapoporometry (EP) wasused to measure the pore-size distributions of the fouled membranes to examine internal fouling, a foulingmodel was applied to extract the fouling parameters, and the interfacial interaction energies werederived. Results indicate that the worst fouling in 30% v/v DMSO was due to both significant externalfouling and internal fouling, whereas the second-worst fouling by 30% v/v IPA was caused predominantlyby internal fouling. The magnitudes of the total DLVO- and XDLVO-based interaction energies were foundto be poorly related to the relative flux declines. This study provides valuable insights into membranefouling in different solvent environments.
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