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      • SCOPUSKCI등재

        Changes in the Thebaine Content of Papaver bracteatum Lindl. after Colchicine Treatment of the Seeds

        Berit Smestad Paulsen,Jens K. Wold,Morten M. Laane Tuva Haugli,Arnold Nordal 한국생약학회 1989 생약학회지 Vol.20 No.2

        Of the Papaveraceae, Papaver somniferum is the most important from a medical and pharmaceutical point of view, since it produces morphine and other alkaloids. 90-95% of the legally produced morphine is used for production of codeine. As P. somniferum and morphine are responsible for a great proportion of the world`s drug problem, a great effort has been made to find other sources for the production of codeine. The Iranian mountain-poppy, P. bracteatum, is producing thebaine as the main alkaloid. Since thebaine also can be converted into codeine, it was of interest to study the production of thebaine in P. bracteatum and try to develop a plant giving a higher yield of thebaine than normally obtained. Seeds of P. bracteatum were treated either with γ-radiation or colchicine in order to create a change in the genetic material in such a way that the production of thebaine is increased. This treatment resulted in several plants giving higher yields of thebaine, and by cultivating plants after vegetative cloning, we obtained plants producing up to 17% thebaine in the capsula. A method for quantitative determination of thebaine has also been developed.

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