Physiology Is a Stronger Predictor of Survival than Pathology in Fibrotic Interstitial Pneumonia

Jegal, Yangjin,Kim, Dong Soon,Shim, Tae Sun,Lim, Chae-Man,Do Lee, Sang,Koh, Younsuck,Kim, Woo Sung,Kim, Won Dong,Lee, Jin Seong,Travis, William D.,Kitaichi, Masanori,Colby, Thomas V. American Thoracic Society 2005 American journal of respiratory and critical care Vol.171 No.6

<P>The histopathologic pattern provides the most important prognostic marker for idiopathic interstitial pneumonia; however, studies have suggested that short-term changes in lung function may be more important. We investigated the prognostic factors for fibrotic interstitial pneumonia. The clinical features and follow-up course of 179 patients (131 with idiopathic pulmonary fibrosis and 48 with nonspecific interstitial pneumonia; 41 fibrotic types and 7 cellular) were analyzed retrospectively. The lung function indices improved or stabilized in most patients with fibrotic nonspecific interstitial pneumonia in contrast to the deterioration or stable condition of most patients with idiopathic pulmonary fibrosis. The 5-year survival of patients with fibrotic nonspecific interstitial pneumonia (76.2%) was better than for those with idiopathic pulmonary fibrosis (43.8%) (p = 0.007). Multivariate analysis at the time of presentation revealed that pathologic pattern, age, and diffusion capacity had important prognostic implications. However, after 6 months of follow-up, changes in FVC, initial diffusion capacity, and sex were the only independent prognostic factors, with no additional prognostic information conferred by the histologic diagnosis. Our data confirmed the importance of physiological parameters including short-term change in FVC. However, at the time of diagnosis, histopathology was important for the prediction of prognosis and future change in lung function.</P>

화학응집제에 의한 전처리 후 폴리아미드 RO-분리막에 의한 염색폐수처리

Jegal Jonggeon,Mo Joonghwan Hwang,Jeong Eun,Lee Kew Ho,Kim Jaephil 한국막학회 2004 멤브레인 Vol.14 No.3

폴리아미드 역삼투막을 이용하여 염색폐수를 처리하였다. 염색폐수를 멤브레인 공정에 적용하기 전에 알럼, 페릭 클로라이드, HOC-100와 같은 화학응집제를 이용하여 먼저 처리하였다. 이러한 전처리가 분리막에 의한 폐수처리 공정에 어떠한 영향을 주는지 알아보기 위하여 최적의 응집/침전 조건을 찾았다. 사용된 모든 응집제에 있어서, 전처리된 폐수의 COD와 UV-흡수도는 약 70% 정도의 감소를 보였다. 이렇게 전처리된 폐수를 다시 분리막 공정으로 처리하였다. 전처리 시 사용된 응집제들이 분리막 공정에서 어떻게 분리막 오염에 영향을 주는지를 조사하였으며, 그 결과 HOC-100가 폐수 내에 존재하는, 분리막 오염을 유발하는 물질 제거에 가장 좋은 효과를 나타내는 것을 알 수 있었다. Treatment of a dyeing wastewater was carried out using polyamide RO-membranes. Before applying the wastewater to the membrane process, it was pretreated with various chemical coagulants such as alum, ferric chloride and HOC-100A. In order to see the effect of the pretreatment on the membrane separation process, the optimum conditions for the coagulation and sedimentation process were sought. As a result, by the pretreatment, for all the coagulants used, the chemical oxygen demand (COD) and UV-absorbance of the wastewater were lowered by more than 70%. The pretreated wastewater was then applied to the membrane process. The effect of the coagulants used for the pretreatment on the membrane fouling was studied. From this study, it was found that the HOC-100A was the best out of the coagulants used for the removal of the materials that could cause membrane fouling.

One-pot synthesis of mixed-valence MoO x on carbon nanotube as an anode material for lithium ion batteries

Jegal, Jong-Pil,Kim, Hyun-Kyung,Kim, Jeom-Soo,Kim, Kwang-Bum Springer-Verlag 2013 Journal of electroceramics Vol.31 No.1

Implementation of three-phase four-leg inverter using SiC MOSFET for UPS applications

Jegal, Jun-Hyeok,Kwon, Minho,Oh, Chang-Yeol,Kim, Kiryong,Lee, Jong-Pil The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.1

This study implemented a 30 kW, 750 V_dc, silicon-carbide (SiC)-based uninterruptible power supply(UPS) applied it on a three-phase four-leg inverter. For component selection, LC filter and DC-link capacitor were designed based on the PSIM simulation. SiC MOSFET was used to achieve higher efficiency and better reliability than the conventional Si IGBT-based UPS applications. Furthermore, desaturation (DeSat) protection method was applied to protect the overcurrent during the short-circuit condition of SiC MOSFET. Thus, the DeSat protection method was applied to SiC MOSFET, thereby enabling a 1 ㎲ protection by complementally switching and zener diode voltage optimization. Accordingly, the transient time of the DeSat protection can be disregarded, thereby enabling fast protection. Meanwhile, several topologies have been studied for unbalanced loads compensation. The current research used a three-phase four-leg inverter topology for compactness and neutral current control. In addition, voltage compensation became possible even in unbalanced load condition by introducing a dual-loop controller for the three-phase four-leg inverter. A dual-loop controller comprises PR and PI controllers to the stationary αβo and synchronous dqo reference frames, respectively. Thermal and efficiency tests were also performed in the rated power test. Under a 30 kW load condition, the surface epoxy molding compound temperature of SiC MOSFET was approximately 72 ℃, and the highest efficiency was approximately 99.1% under 10 kW load condition. Finally, the effectiveness of the implementation was demonstrated through the experiment results.

Tyrosinase inhibitory flavonoid from <i>Juniperus communis</i> fruits

Jegal, Jonghwan,Park, Sang-a,Chung, KiWung,Chung, Hae Young,Lee, Jaewon,Jeong, Eun Ju,Kim, Ki Hyun,Yang, Min Hye Informa UK (TaylorFrancis) 2016 Bioscience, biotechnology, and biochemistry Vol.80 No.12

<P>The fruits of Juniperus communis have been traditionally used in the treatment of skin diseases. In our preliminary experiment, the MeOH extract of J. communis effectively suppressed mushroom tyrosinase activity. Three monoflavonoids and five biflavonoids were isolated from J. communis by bioassay-guided isolation and their inhibitory effect against tyrosinase was evaluated. According to the results of all isolates, hypolaetin 7-O--xylopyranoside isolated from J. communis exhibited most potent effect of decreasing mushroom tyrosinase activity with an IC50 value of 45.15M. Further study provided direct experimental evidence for hypolaetin 7-O--D-xylopyranoside-attenuated tyrosinase activity in -MSH-stimulated B16F10 murine melanoma cell. Hypolaetin 7-O--D-xylopyranoside from the EtOAc fraction of J. communis was also effective at suppressing -MSH-induced melanin synthesis. This is the first report of the enzyme tyrosinase inhibition by J. communis and its constituent. Therapeutic attempts with J. communis and its active component, hypolaetin 7-O--D-xylopyranoside, might be useful in treating melanin pigmentary disorders.</P>

Surface engineering of titanium with simvastatin-releasing polymer nanoparticles for enhanced osteogenic differentiation

Jegal, J. H.,Choi, G. H.,Lee, H. J.,Kim, K. D.,Lee, S. C. THE POLYMER SOCIETY OF KOREA 2016 Macromolecular Research Vol.24 No.1

<P>We describe a novel approach for surface engineering of titanium (Ti) with polymer nanoparticles that can sustainably release an osteogenic compound, simvastatin (SV). The SV-loaded nanoparticles (SV-GC-CA) were prepared by self-assembly of 5 beta-cholanic acid-conjugated glycol chitosan (GC-CA) in the presence of SV. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) analyses showed that the SV-GC-CA nanoparticles had a hydrodynamic diameter of 371.4 nm with a spherical shape. The surface engineering of Ti was performed by pre-treatment of Ti surface with polydopamine (PD) coatings, followed by immobilization of the SV-GC-CA nanoparticles. The immobilization of the SV-GC-CA nanoparticles onto PD-treated Ti surfaces could be achieved by a simple dipping method in an aqueous solution. The successful immobilization of the SV-GC-CA nanoparticles onto Ti surfaces was confirmed by field-emission scanning electron microscopy (FE-SEM), and the density of immobilized nanoparticles could be controlled. SV was sustainably released for up to 20 days, and the release rate was dependent on the loading amount of SV. The Ti substrate functionalized with SV-releasing nanoparticles significantly promoted alkaline phosphatase (ALP) activity of osteoblast-like cells (MC3T3-E1). The surface engineering approach described in this work has an applicability for various medical devices to generate surfaces with improved osteogenic potentials.</P>

Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress

Jegal, K. H.,Ko, H. L.,Park, S. M.,Byun, S. H.,Kang, K. W.,Cho, I. J.,Kim, S. C. Springer Science + Business Media 2016 Apoptosis Vol.21 No.5

<P>Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) has many pharmacological activities including anti-inflammation, anti-oxidant and anti-cancer effects. Autophagy is the basic cellular machinery involving the digestion of damaged cellular components. In the present study, we investigated the protection effects of eupatilin against arachidonic acid (AA) and iron-induced oxidative stress in HepG2 cells and tried to elucidate the molecular mechanisms responsible. Eupatilin increased cell viability against AA + iron in a concentration-dependent manner and prevented mitochondrial dysfunction and reactive oxygen species (ROS) production. In addition, AA + iron increased the levels of pro-apoptotic proteins and these changes were prevented by eupatilin. Eupatilin also induced autophagy, as evidenced by the accumulation of microtubule-associated protein 1 light chain3-II and the detection of autophagic vacuoles. Furthermore, the protective effects of eupatilin on mitochondrial dysfunction and ROS production were significantly abolished by autophagy inhibitors. Eupatilin also increased the mRNA level of sestrin-2 and its promoter-driven reporter gene activity, which resulted in the up-regulation of sestrin-2 protein. Finally, gene silencing using sestrin-2 siRNA and the ectopic expression of recombinant adenoviral sestrin-2 indicated that sestrin-2 induction by eupatilin was required for autophagy-mediated cytoprotection against AA + iron. Our results suggest that eupatilin activates sestrin-2-dependent autophagy, thereby preventing oxidative stress induced by AA + iron.</P>

Juniperus chinensis Fruits Attenuate Oxazolone- and 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms in Mice

Jegal, J.,Park, N.-J.,Park, S.,Bong, S.-K.,Jegal, H.,Kim, S.-N.,Yang, M. H. PHARMACEUTICAL SOCIETY OF JAPAN 2018 Biological & pharmaceutical bulletin Vol.41 No.2

The Influence of Body Support Treadmill Training with Visual Feedback on the Gait Factors of Stroke Patients

Jegal, Hyuk,Kim, Ki Jong,Jun, Hyun Ju International Academy of Physical Therapy Research 2014 Journal of International Academy of Physical Ther Vol.5 No.2

The aim of this research was to investigate how the effects of body supported treadmill training with visual feedback affect the gait factors of stroke patients. Thirty subjects (21 male, 9 female) with a diagnosis of stroke were taken to the hospital to participate in this study. The subjects received body supported treadmill training with visual feedback. The training was executed for 6 minutes, 3 times a day per week for 19 weeks after general exercise. The effects of the visual feedback in the body supported treadmill training were evaluated by measuring the average gait cycle and the average step length of the affected and unaffected. The collected data were statistically analyzed by using a paired t-test. The results of this study were a significant improvement of the average gait cycle and no statistically significant difference of the average step length. The gait cycle average had a statistically significant difference in gender, age, etiology, paretic side, and step length average. There was no statistically significant difference in infarction within etiology. Therefore, it was necessary to apply the easy and simple with the treadmill training in the rehabilitation of the stroke patients. This study will require a variety of outcome measures related to the effects of treadmill training with gait factors.

The Utility of a Three-Dimensional Approach with T-Shaped Osteotomy in Osseous Genioplasty

Jegal, Jung Jae,Kang, Seok Joo,Kim, Jin Woo,Sun, Hook Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.4

Background Facial beauty depends on the form, proportion, and position of various units of the face. In terms of the frontal view and facial profile, the chin is the most prominent aesthetic element of the lower third of the face. Many methods have been implemented to obtain good proportions of the lower face. In this study, we applied the T-shaped genioplasty method to correcting chin deformities. Methods All of the procedures in 9 cases were performed under general anesthesia. For genioplasty, a horizontal cutting line and 1 or 2 vertical cutting lines were drawn 5 mm below the mental foramen. Osteotomed bone segments of the chin were used for horizontal widening using bone grafts or for horizontal shortening. Likewise, they were used as bone grafts for vertical lengthening or vertical shortening. The bone segments were approximated in the midline and held in place using miniplates. Results The postoperative appearance of the 9 cases showed that the lower third of the face had been naturally changed. At the same time, vertical lengthening or shortening, and horizontal widening or shortening could be implemented during the operation. Satisfactory results were obtained based on reviews of the patients' preoperative and postoperative photographs. The patients were also satisfied with the outcomes. Conclusions Using T-shaped genioplasty, we efficiently adjusted the shape and position of the chin to obtain good proportions of the lower face and change its contour to obtain an aesthetically appealing oval face in accordance with East Asians' aesthetic preferences.