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- 저자 : Ismail Oguz Kara (검색결과 2 건)
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A New Approach to the Treatment of Metastatic Paraganglioma: Sorafenib
Meral Gunaldi,Ismail Oguz Kara,Berna Bozkurt Duman,Cigdem Usul Afsar,Melek Ergin,Arbil Avci 대한암학회 2014 Cancer Research and Treatment Vol.46 No.4
Paragangliomas are relatively rare chromaffin cell tumors which may be cured throughresection. Patients with paragangliomas may develop metastatic diseases. There isno consensus regarding refractory chemotherapy for treatment of metastatic disease. In this report, we presented a case of a 43-year-old woman who was admitted to thehospital with a history of episodic headaches, diaphoresis, and weakness. Elevatedplasma catecholamine levels and a right paraaortic mass were observed on computedtomography. The mass was excised, and a diagnosis of paraganglioma was confirmed. After 20 months of follow-up, local recurrence and metastases were detected in thethorax, abdomen, and skeletal system. Plasma and urinary catecholamine levels werehigh. Chemotherapy was administered, and no improvement was observed. Therefore,following this palliative conventional chemotherapy, sorafenib was administered forthree months, and, finally, positron emission tomography showed that the patient’slesions had completely regressed.
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Afsar, Cigdem Usul,Gunaldi, Meral,Kum, Pinar,Sahin, Berksoy,Erkisi, Melek,Kara, Ismail Oguz,Paydas, Semra,Duman, Berna Bozkurt,Ercolak, Vehbi,Karaca, Feryal,Uyeturk, Ummugul,Guner, Sebnem Izmir Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Background: The aim of this study was to investigate the general characteristics of patients with deep vein thrombosis (DVT) and pancreatic cancer as well as evaluate the relationship between mean platelet volume (MPV), DVT and survival. Materials and Methods: Seventy-seven patients with pancreatic cancer, who were admitted to Cukurova University Medical Faculty, Department of Medical Oncology, were enrolled in the study Results: The mean age was $59{\pm}20$. Forty-nine (63.6%) were men and 28 women (36.4%). Sixty-eight (88.3%) patients had adenocarcinoma and 9 (11.7%) had a malignant epithelial tumor. Thirty-six (46.7%) had liver metastasis at diagnosis. Twenty-six (33.8%) patients were alive, 20 (26%) were dead and in 31 (40.2%) the status was unknown. Only 14 (18.1%) patients had DVT. In 42 (54.5%) patients MPV values were normal, in 28 (36.4%) patients they were above normal, and in 7 (9.1%) patients they were below normal. There was no statistically significant difference between gender, tumour localization, chemotherapy and survival rates (p:0.56, p:0.11, p:0.21). There was no significant difference between DVT, gender, localisation, histological subtype, the presence of metastasis, stage and if the patient had been treated with chemotherapy (p:0.5, p:0.6, p:0.2, p:0.32, p:0.1, p:0.84). There was also no significant difference between MPV and DVT (p:0.57) but there was a significant difference between liver metastasis and DVT (p:0.02). Age, stage, the presence of metastasis and DVT were prognostic in pancreatic cancer patients. Conclusions: Cases of pancreatic cancer with liver metastasis should be studied more carefully as thrombosis is more common in these patients.
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