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RISS 인기검색어
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- 저자 : Inoue Taro (검색결과 3 건)
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Persistence of Denosumab Therapy among Patients with Osteoporosis
Kobayashi Kazuyoshi,Ando Kei,Machino Masaaki,Morozumi Masayoshi,Kanbara Shunsuke,Ito Sadayuki,Inoue Taro,Yamaguchi Hidetoshi,Ishiguro Naoki,Imagama Shiro 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.4
Study Design: Retrospective study in a single center.Purpose: To examine denosumab persistence in patients of different ages with severe osteoporosis in Japan.Overview of Literature: Denosumab is an antibody drug used for the treatment of osteoporosis. It is mainly used in patients with severe osteoporosis who might have high motivation for treatment, and the need for only semi-annual subcutaneous injection might improve the continuation rate. However, no English-language articles have reported on denosumab persistence in the Japanese population, including young people, despite the importance of this issue in a super-aging society. Methods: The subjects started treatment with subcutaneous denosumab in our department from July 2013 until December 2017. Persistence rates were calculated using Kaplan-Meier curves. Patients were defined as “persistent” or “non-persistent” according to the use of therapy after 60 months.Results: The study included 101 patients (84 females) with a median follow-up period of 23.6±14.2 months. The persistence rate declined to 85.3%, 78.3%, 74.1%, 71.3%, and 69.3% at 12, 24, 36, 48, and 60 months, respectively. Age at the initiation of denosumab therapy differed significantly between non-persistent (n=31) and persistent (n=70) patients (81.3 vs. 72.8 years, <i>p</i> <0.01). Persistence was significantly lower in patients aged ≥80 years than in those aged <60 and 60–79 years (both <i>p</i> <0.01). The reasons for non-persistence of denosumab therapy were transfer to another hospital (n=13), interruption of outpatient visits (n=11), dental treatment (n=4), adverse events (n=2), and patient request (n=1).Conclusions: Persistence was significantly lower in patients aged ≥80 years than in patients of other ages, and strategies promoting persistence are needed for these elderly patients.
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Ito Sadayuki,Sakai Yoshihito,Harada Atsushi,Ando Kei,Kobayashi Kazuyoshi,Nakashima Hiroaki,Machino Masaaki,Kambara Shunsuke,Inoue Taro,Hida Tetsuro,Ito Kenyu,Ishiguro Naoki,Imagama Shiro 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.5
Study Design: Retrospective study. Purpose: We aimed to use motor evoked potentials (MEPs) to examine the association of electrophysiological assessment of the trapezius muscle with neck pain. Overview of Literature: Previous reports on the association of neck pain with the trapezius muscle have focused on surface electromyograms and muscle oxygenation; however, to our knowledge, none of these studies included detailed data on MEPs. Methods: The study included 100 patients with cervical myelopathy who underwent surgery at the National Center for Geriatrics and Gerontology in Obu, Japan from June 2010 to March 2013. Before the surgery, neck pain was evaluated using a Visual Analog Scale (a score ≥50 indicated neck pain and a score <50 indicated no neck pain). The preoperative cross-sectional areas of the trapezius muscles were measured with cervical magnetic resonance imaging sagittal T2-weighted images. Cranial stimulation under general anesthesia was used to derive the MEPs, enabling the measurement of latency and amplitude, using preoperative MEPs of the trapezius muscles. Results: The MEP of the trapezius muscle in patients with neck pain had significantly shorter latencies than those in patients who did not have neck pain. However, there was no significant difference in the amplitude between patients with and without neck pain. However, this tended to be greater in patients with neck pain as compared to that in those without neck pain. The cross-sectional area of the trapezius muscle in patients with neck pain was significantly smaller than that in those who did not have neck pain. Conclusions: MEPs revealed electrophysiological abnormalities of the trapezius muscles in patients with neck pain, supporting a relationship of neck pain with the trapezius muscles.
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Scoliosis Caused by Limb-Length Discrepancy in Children
Kobayashi Kazuyoshi,Ando Kei,Nakashima Hiroaki,Machino Masaaki,Morozumi Masayoshi,Kanbara Shunsuke,Ito Sadayuki,Inoue Taro,Yamaguchi Hidetoshi,Mishima Kenichi,Ishiguro Naoki,Imagama Shiro 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.6
Study Design: Single-center retrospective study in pediatric patients.Purpose: The purpose of the study was to investigate the effects of the presence and severity of leg-length discrepancy (LLD) on scoliosis in children.Overview of Literature: LLD is a common orthopedic problem that can result in standing imbalance, low back pain, and stress fractures. It may cause structural changes in the spine over time, but the exact effect of LLD on scoliosis is unknown.Methods: The subjects were 23 children with LLD ≥20 mm (range, 27–65 mm) treated at Nagoya University Hospital between 2007 and 2017. Whole spine posteroanterior standing radiographs and whole lower limb radiographs in a supine position were recorded. Data were collected for demographics, LLD, Cobb angle, pelvic obliquity, and Nash/Moe index. Scoliosis was defined as a Cobb angle ≥10°. Leg length was measured from the top of the femoral head to the middle of the tibial plafond, and LLD was defined as the difference between the left and right leg lengths.Results: The patients (nine males and 14 females) had a mean age of 14.0 years (range, 5–18 years). The average LLD was 44.3±17.2 mm, with LLDs of 20 to 39 mm, 40 to 59 mm, and ≥60 mm in 13, five, and five subjects, respectively. The average Cobb angle was 13.0°±7.0°, and 15 subjects (65%) had scoliosis. Convexity of the scoliosis was to the short leg side in all cases. The Cobb angle was significantly related to the severity of the LLD (<i>R</i>=0.736, <i>p</i><0.01), pelvic obliquity (<i>R</i>=0.966, <i>p</i><0.01), and Nash/Moe index (<i>p</i><0.05).Conclusions: LLD is a common pediatric condition that can cause scoliosis of the spine. Severe scoliosis may develop if the LLD is ≥30 mm. Long-term studies are needed to examine the effect of LLD resolution on the elimination of scoliosis.
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