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Measuring T1 contrast in ex-vivo prostate tissue at the Earth’s magnetic field
Sangwon Oh,한재호,Ji Eun Kwon,심정현,이성주,황성민,Ingo Hilschenz,김기웅 한국자기공명학회 2019 Journal of the Korean Magnetic Resonance Society Vol.23 No.1
A former study has shown that the spin-lattice relaxation time (T1) in cancerous prostate tissue had enhanced contrast at an ultra-low magnetic field, 132 uT. To study the field dependence and the origin of the contrast we measured T1 in pairs of ex-vivo prostate tissues at the Earth’s magnetic field. A portable and coil-based nuclear magnetic resonance (NMR) system was adopted for T1 measurements at 40 uT. The T1 contrast, delta = 1 - T1 (more cancer)/T1(less cancer), was calculated from each pair. Additionally, we performed pathological examinations such as Gleason’s score, cell proliferation index, and micro-vessel density (MVD), to quantify correlations between the pathological parameters and T1 of the cancerous prostate tissues.
Measuring T<sub>1</sub> contrast in ex-vivo prostate tissue at the Earth's magnetic field
Oh, Sangwon,Han, Jae Ho,Kwon, Ji Eun,Shim, Jeong Hyun,Lee, Seong-Joo,Hwang, Seong-Min,Hilschenz, Ingo,Kim, Kiwoong Korean Magnetic Resonance Society 2019 Journal of the Korean Magnetic Resonance Society Vol.23 No.1
A former study has shown that the spin-lattice relaxation time ($T_1$) in cancerous prostate tissue had enhanced contrast at an ultra-low magnetic field, $132{\mu}T$. To study the field dependence and the origin of the contrast we measured $T_1$ in pairs of ex-vivo prostate tissues at the Earth's magnetic field. A portable and coil-based nuclear magnetic resonance (NMR) system was adopted for $T_1$ measurements at $40{\mu}T$. The $T_1$ contrast, ${\delta}=1-T_1$ (more cancer)/$T_1$(less cancer), was calculated from each pair. Additionally, we performed pathological examinations such as Gleason's score, cell proliferation index, and micro-vessel density (MVD), to quantify correlations between the pathological parameters and $T_1$ of the cancerous prostate tissues.
Lee, Seong-Joo,Shim, Jeong Hyun,Yu, Kwon Kyu,Hwang, Seong-min,Oh, Sangwon,Hilschenz, Ingo,Kim, Kiwoong BUREAU INTERNATIONAL DES POIDS ET MESURES 2019 METROLOGIA -BERLIN- Vol.56 No.4
<P>Overhauser dynamic nuclear polarization (O-DNP) can significantly boost the intensity of the nuclear magnetic resonance (NMR) signal in comparison to the thermal magnetization for field strengths in the microtesla range. We demonstrate the development and use of an Overhauser spin-echo magnetometer using a superconducting quantum interference device-based microtesla NMR system and dissolved nitroxide radicals in deoxygenated tetramethylsilane liquid. A spin-echo train with an enhanced signal was successfully obtained with the O-DNP technique. A magnetic field strength of about 0.92 <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/0026-1394/56/4/045011/metab2fadieqn003.gif'/>T was measured with an uncertainty of 0.7 pT in the presence of a field gradient of 0.038 <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/0026-1394/56/4/045011/metab2fadieqn004.gif'/>T cm<SUP>−1</SUP>. The Overhauser proton spin-echo magnetometer will be useful for the measurement of low magnetic fields by minimizing the generation of disturbing magnetic fields without the need to compensate for residual field gradients.</P>