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Assessment of neutron-induced activation of irradiated samples in a research reactor
Harsányi Ildikó,Horváth András,Kis Zoltán,Gméling Katalin,Jozwiak-Niedzwiedzka Daria,Glinicki Michal A.,Szentmiklósi László 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3
The combination of MCNP6 and the FISPACT codes was used to predict inventories of radioisotopes produced by neutron exposure of a sample in a research reactor. The detailed MCNP6 model of the Budapest Research Reactor and the specific irradiation geometry of the NAA channel was established, while realistic material cards were specified based on concentrations measured by PGAA and NAA, considering the precursor elements of all significant radioisotopes. The energy- and spatial distributions of the neutron field calculated by MCNP6 were transferred to FISPACT, and the resulting activities were validated against those measured using neutron-irradiated small and bulky targets. This approach is general enough to handle different target materials, shapes, and irradiation conditions. A general agreement within 10% has been achieved. Moreover, the method can also be made applicable to predict the activation properties of the near-vessel concrete of existing nuclear installations or assist in the optimal construction of new nuclear power plant units.
Gergely Temesi,Viktor Virág,Éva Hadadi,Ildikó Ungvári,Lili E Fodor,András Bikov,Adrienne Nagy,Gabriella Gálffy,Lilla Tamási,Ildikó Horváth,András Kiss,Gábor Hullám,András Gézsi,Péter Sárközy,Péter Ant 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.6
Purpose:Based on a previous gene expression study in a mouse model of asthma, we selected 60 candidate genes and investigated their possible roles in human asthma. Methods: In these candidate genes, 90 SNPs were genotyped using MassARRAY technology from 311 asthmatic children and 360 healthy controls of the Hungarian (Caucasian) population. Moreover, gene expression levels were measured by RT PCR in the induced sputum of 13 asthmatics and 10 control individuals. t-tests, chi-square tests, and logistic regression were carried out in order to assess associations of SNP frequency and expression level with asthma. Permutation tests were performed to account for multiple hypothesis testing. Results: The frequency of 4 SNPs in 2 genes differed significantly between asthmatic and control subjects: SNPs rs2240572, rs2240571, rs3735222 in gene SCIN, and rs32588 in gene PPARGC1B. Carriers of the minor alleles had reduced risk of asthma with an odds ratio of 0.64 (0.51-0.80; P=7×10-5) in SCIN and 0.56 (0.42-0.76; P=1.2×10-4) in PPARGC1B. The expression levels of SCIN, PPARGC1B and ITLN1 genes were significantly lower in the sputum of asthmatics. Conclusions: Three potentially novel asthma-associated genes were identified based on mouse experiments and human studies.