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RISS 인기검색어
- 검색키워드
- 저자 : Ichinose Noboru (검색결과 3 건)
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Zinc-containing tricalcium phosphate and related materialsfor promoting bone formation
Atsuo Ito,Makoto Otsuka,Haruo Kawamura,Masako Ikeuchi,Hajime Ohgushi,Yu Sogo,Noboru Ichinose 한국물리학회 2005 Current Applied Physics Vol.5 No.5
Calcium phosphate is a suitable carrier of zinc, an essential element that has stimulatory effects on bone formation in vitro and in vivo as well as an inhibitory effect on osteoclastic bone resorption in vitro. The highest zinc content is attained in b-tricalcium phosphate, where the zinc content reaches 6 wt%. Both rat and human bone marrow cells (BMCs) cultured on zinc-containing b-tricalcium phosphate and hydroxyapatite composite ceramics differentiated more than BMCs cultured on zinc-free composite ceramics in the presence of b-glycerophosphate and dexamethasone. The acceptable dose of zinc was higher for human BMCs than for rat BMCs. The solubility of ZnTCP, which contains a nontoxic level of zinc, decreased to 52–92% that of pure TCP in the pH range of 5.0–7.4. However, the resorbed volume of ZnTCP was much lower than that expected from the in vitro solubility of ZnTCP, becoming as low as 26–20% that of TCP, which indicates that the reduction in the resorbability of ZnTCP would be attributable principally to its lowered cellular activation property relative to that associated with pure TCP. Probably due to the lowered cellular activation property associated with ZnTCP, bone loss at the bone-implant interface was significantly arrested in the longterm implantation of ZnTCP/HAP. The intramuscular injection of ZnTCP powder is effective in increasing bone mineral density in the vicinity of the injected site in osteopenic animals. All these findings suggest that zinc-containing calcium phosphate is a biomaterial that promotes bone formation.
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Coprecipitation of cytochrome C with calcium phosphateon hydroxyapatite ceramic
Yu Sogo,Atsuo Ito,Koshiro Fukasawa,Nao Kondo,Yusuke Ishikawa,Noboru Ichinose,Atsushi Yamazaki 한국물리학회 2005 Current Applied Physics Vol.5 No.5
Cytochrome C (cyt C), which has a molecular weight and an isoelectric point similar to those of broblast growth factor(FGF-2), was coprecipitated with calcium phosphates in the presence or absence of a hydroxyapatite ceramic (HAP) using super-saturated calcium phosphate solutions that can be prepared by mixing infusion uids. The precipitates formed in the solutionconsisted of amorphous calcium phosphate in the absence of a HAP. In the presence of a HAP, precipitates morphologically iden-tical to bone-like apatite formed a calcium phosphate layer on the surface of HAP. The optimum conditions for coprecipitation ofcyt C with calcium phosphate on HAP were a Ca/P molar ratio of 1.5 and a NaHCO3 concentration of 7.90 mM. The release of cytis also expected to be coprecipitated with calcium phosphates onto HAPs using infusion fluids..
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Fluoride single crystals for UV/VUV nonlinear optical applications
Shimamura Kiyoshi,Villora Encarnacion G.,Muramatsu Kenichi,Kitamura Kenji,Ichinose Noboru The Korea Association of Crystal Growth 2006 한국결정성장학회지 Vol.16 No.4
The growth characteristics and properties of large size $SrAlF_5$ single crystals are described and compared with those of $BaMgF_4$. Transmission spectra in the vacuum ultraviolet wavelength region indicate a high transparency of $SrAlF_5$ (about 90% without considering surface reflection loses) down to 150 nm, on contrast to the optical loses observed for $BaMgF_4$. The ferroelectric character of $SrAlF_5$ is evidenced by the reversal of the spontaneous polarization in a hysteresis loop. The higher potential of $SrAlF_5$ in comparison with $BaMgF_4$ for the realization of all-solid-state lasers in the ultraviolet wavelength region by the quasi-phase matching (QPM) technique is pointed out. $SrAlF_5$, besides a higher grade of transparency, shows a nonlinear effective coefficient similar to that of quartz and uniaxial nature, on contrast to the one order smaller nonlinear coefficient and biaxial character of $BaMgF_4$. The refractive index of $SrAlF_5$ from the ultraviolet to the near-infrared wavelength region is measured by the minimum deviation method. The Sellmeier and Cauchy coefficients are obtained from the fits to the curves of the ordinary and extraordinary refractive indices, and the grating period for the first order QPM is estimated as a function of the wavelength. The poling periodicity for 193 nm SHG from 386 nm is $4{\mu}m$.
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