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( Hye-jin Jung ),( Seung-soon Im ),( Dae-kyu Song ),( Jae-hoon Bae ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.6
Lysophosphatidylcholine (LPC) is a major phospholipid com-ponent of oxidized low-density lipoprotein (ox-LDL) and is implicated in its atherogenic activity. This study investigated the effects of LPC on cell viability, intracellular calcium homeostasis, and the protective mechanisms of chlorogenic acid (CGA) in human umbilical vein endothelial cells (HUVECs). LPC increased intracellular calcium ([Ca<sup>2+</sup>]i) by releasing Ca<sup>2+</sup> from intracellular stores and via Ca<sup>2+</sup> influx through store-operated channels (SOCs). LPC also increased the generation of reactive oxygen species (ROS) and decreased cell viability. The mRNA expression of Transient receptor potential canonical (TRPC) channel 1 was increased signifi-cantly by LPC treatment and suppressed by CGA. CGA inhibited LPC-induced Ca<sup>2+</sup> influx and ROS generation, and restored cell viability. These results suggested that CGA inhibits SOC-mediated Ca<sup>2+</sup> influx and ROS generation by attenuating TRPC1 expression in LPC-treated HUVECs. Therefore, CGA might protect endothelial cells against LPC injury, thereby inhibiting atherosclerosis. [BMB Reports 2017; 50(6): 323-328]
Hye Jin Jung,Young-Ho Kim,김유선,Seong Yeon Jeong,Sung Won Park,Ji Yeon Seo,Hyemi Jung,Jong Pil Im,Ji Won Kim,Sung Noh Hong,Kuk Lae Lee 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.4
Intestinal tuberculosis (ITB) remains prevalent in Asia. An interferon-γ assay (QuantiFERON-TB gold test [QFT]) is considered to be an effective supplementary tool for diagnosing ITB. We retrospectively analyzed the clinical features of ITB patients based on the initial results of QFT. A total of 109 patients with ITB were enrolled, and 82 patients (75.2%) showed positive QFT results. In the QFT-positive group, the mean age (44.1±12.0 years) was significantly higher than that in the QFT-negative group (37.0±14.8, p=0.0096). Abdominal pain (p=0.006) and diarrhea (p=0.030) were more frequent in the QFT-negative group. Further, C-reactive protein (CRP) levels were significantly higher in the QFTnegative group (6.4±9.9 mg/dL) than in the QFT-positive group (1.3±2.3, p<0.001). Multivariate analysis confirmed that younger age (p=0.016), diarrhea (p=0.042), and high levels of CRP (p=0.029) were independent predictors of QFTnegative results in patients with ITB. These results suggest that prior exposure to TB, reflected by QFT positivity, may cause mild inflammation in patients with ITB.
( Hye Jin Jung ),( You Sun Kim ),( Song Yi Bae ),( Ji Yeon Seo ),( Hyemi Jung ),( Jong Pil Im ),( Ji Won Kim ),( Sung Noh Hong ),( Young Ho Kim ),( Kuk Lae Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Intestinal tuberculosis (ITB) is still prevalent in Korea. Recently, the incidence of Crohn`s disease (CD) is also increasing, therefore, differential diagnosis of CD from ITB is challenging. An INF-gamma assay (QuantiFERON-TB gold test, QFT) is regarded as a good supplementary tool for the diagnosis of ITB. However, the clinical implication of the positive results of QFT in ITB is uncertain. We investigated the clinical features of patients of ITB according to the results of QFT. Methods: We enrolled the ITB patients who were tested for QFT in the initial diagnosis from April 2007 to July 2013. We retrospectively analyzed clinical features of ITB patients based on the results of QFT. Results: A total of 109 patients with ITB were enrolled from 3 institutes and 82 patients (75.2%) showed positive results of QFT, whereas 27 patients (24.8%) showed negative results. In QFT-positive group, the mean age at the time of diagnosis as ITB is 44.1±12 years, which is significantly higher than QFT-negative group (37±14.8 years, p=0.0096). In addition, QFT-positive group showed more history of previous BCG injection than QFT-negative group (P=0.009). C-reactive protein level at the time of diagnosis as ITB is signifi cantly lower in QFT-positive group (1.3±2.3 mg/dL) than QFT-negative group (6.4±9.9 mg/dL, P<0.000). However, no differences was found between groups regarding the presence of granuloma in colonic tissues (P=0.095), accompanying of extraintestinal TB (P=0.592), or the level of ESR (P=0.978). Conclusions: QFT-positive results were gained in three-fourths patients with ITB and we confi rmed that QFT is a good supplementary tool for the diagnosis of ITB. In QFT-positive group, the mean age is higher and has more history of BCG injection than QFT-negative group, suggesting the positive correlation between QFT and BCG injection.
Review on Influencing Factors for the Selection of the Waste Routes in a Decommissioning Project
Hye Jin Jung,Hyu Chang Choi,Kwang Ho Jo,Byong Sop Lim,Jin Won Son 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.1
Kori Nuclear Power Plant Unit 1, which began operating in 1978, is Korea’s oldest commercial nuclear reactor. The reactor was permanently shut down in June 2017, and now the decommissioning process has begun. The decommissioning process will generate a significant amount of waste that requires appropriate management to minimize the impact on the environment and human health. And the waste routing, i.e. the activities and logistics for managing the material generated, is a key point in a decommissioning project. It determines the routes from the material inventory to the envisaged material end states. In this study, we review on several factors for the selection of the waste routes in a decommissioning project. In terms of sustainability, the ‘waste hierarchy’ should be applied to routing materials from nuclear facilities. According to the waste hierarchy, the preferred end state is reuse or recycling of the waste as material or, more preferably, the avoidance of waste generation. In addition, treatments (such as decontamination and thermal treatment) that can reduce the volumes requiring disposal as radioactive waste should be considered. Another important parameter is the need to secure availability and capacity of waste routes. Short-term bottlenecks or any delay in the removal of the waste from the site often has an impact on other site activities. If possible, at least two alternative waste routes should be identified for the main categories of waste and kept available throughout the decommissioning project. All routes should be direct to the material end state if possible, but it is more important that waste is removed from the site so that other site operations are not impeded.
Hye Jin Jung,Kwang Ho Jo,Hyu Chang Choi,Byong Sop Lim,Jin Won Son 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.1
As an initial part of Kori-1 & Wolsung-1 Unit decommissioning planning, a characterization plan is developed to define the nature, extent and location of contaminants, determine sampling locations and protocols, determine quality assurance objectives for characterization, and define documentation requirements. The actual characterization of a facility is an iterative process that involves initial sampling according to the characterization plan, field management (such as labeling, packaging, storing, and transport) of the samples, laboratory analysis, conformance to the data quality objectives (DQOs), and then identifying any additional sampling required, refining the DQOs, and modifying the characterization plan accordingly. The final product of the facility characterization is a document that describes the type, amount, and location of contaminants that will require consideration and removal during the decommissioning operations sufficient to prepare a decommissioning plan. In this study, implementing a characterization plan, developed in accordance with this standard, will result in obtaining or deriving the above information.