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Huseyin Atasoy,Esen Yildirim 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.7
In this study, electroencephalography signals recorded while participants were doing verbal and quantitative tasks, are classified. A dataset containing 1044 records obtained from 18 participants are used for subject-dependent classifications. Features are derived from phase locking values calculated between all channel pairs. Features are reduced before the classification process by using both analysis of variance and correlation based feature selection methods. Instances in the dataset are classified by using the nearest neighbor algorithm. An average classification accuracy of 92.35% is achieved over 18 participants. It is shown that phase locking value is distinctive especially when it is calculated on delta and gamma frequency bands measured between frontal and occipital regions.
Are There Standardized Cutoff Values for Neutrophil-Lymphocyte Ratios in Bacteremia or Sepsis?
( Gonul Gurol ),( Ihsan Hakki Ciftci ),( Huseyin Agah Terzi ),( Ali Riza Atasoy ),( Ahmet Ozbek ),( Mehmet Koroglu ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.4
Bacteremia and sepsis are common causes of morbidity and mortality worldwide, with incorrect or delayed diagnoses being associated with increased mortality. New tests or markers that allow a more rapid and less costly detection of bacteremia and sepsis have been investigated. The aim of this study was to clarify the cutoff value of the neutrophillymphocyte ratio (NLR) according to procalcitonin (PCT) level in the decision-making processes for bacteremia and sepsis. In addition, other white blood cell subgroup parameters, which are assessed in all hospitals, for bacteremia and sepsis were explored. This retrospective study included 1,468 patients with suspected bacteremia and sepsis. Patients were grouped according to the following PCT criteria: levels <0.05 ng/ml (healthy group), 0.05-0.5 ng/ml (local infection group), 0.5-2 ng/ml (systemic infection group), 2-10 ng/ml (sepsis group), and >10 ng/ml (sepsis shock group). One important finding of this study, which will serve as a baseline to measure future progress, is the presence of many gaps in the information on pathogens that constitute a major health risk. In addition, clinical decisions are generally not coordinated, compromising the ability to assess and monitor a situation. This report represents the first study to determine the limits of the use of NLR in the diagnosis of infection or sepsis using a cutoff value of <5 when sufficient exclusion criteria are used.
Prognostic impact of p16 and p53 gene expressions in stage 1a epithelial ovarian cancer
( Emre Gunakan ),( Yusuf Aytac Tohma ),( Latife Atasoy Karakaş ),( Huseyin Akıllı ),( Asuman Nihan Haberal ),( Ali Ayhan ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.4
Objective Epithelial ovarian cancer (EOC) is rarely detected at stage 1a. Most of the patients have a good prognosis and there are limited factors that affect their survival. In the present study, we evaluated the p16 and p53 gene expressions of stage 1a EOC patients. Prognostic effects of these gene expressions, as well as those of other factors on short term survival were analyzed. Methods Our study included 29 patients. The specimens of the ovary with cancer were stained for p16 and p53. Gene expressions and other prognostic factors were evaluated. Results The median age of the patients was 51 years (27-84). The mean numbers of dissected pelvic and paraaortic lymph nodes were 27 and 12, respectively. The mean follow-up time was 33.7±18.9 months. During this period, recurrence occurred in two patients. One of the patients had grade 2 mucinous carcinoma and died of the disease at month 12 after the recurrence occurred at month 7. The second patient had clear cell carcinoma and recurrence occurred at month 34. p16 and p53 gene expressions or other factors were not associated with overall survival (OS) or diseasefree survival in the short term. The lower p16 positivity rate in the non-clear cell group was found to be statistically significant (P=0.003). Both p53 and p16 positivity rates were higher in the high-grade carcinoma. Conclusion The levels of none of the common prognostic factors, including those of p16 and p53 gene expression, were associated with the progression-free survival or OS of stage 1a in the short term. Appropriate surgical staging and non-omission of subclinical metastases seem to be of central importance.