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Xiaohua Liu,Zhenlin Hu,Qirong Shi,Huawu Zeng,Yunheng Shen,Huizi Jin,Wei-Dong Zhang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.7
Radix Tinosporae is a herb widely used in traditional Chinese medicine for the treatment of various inflammatory diseases. In the present study, its anti-inflammatory and antinociceptive activities were investigated. The ethanol extract of Radix Tinosporae exhibited significant inhibitory effects on xylene-induced ear edema and acetic acid-induced writhing in mice. Using bioassay-guided fractionation, the n-butanol fraction was determined as the active fraction. Further purification of the most active n-butanol fraction led to the isolation of three compounds, palmatine, columbamine and columbinyl glucoside. All three compounds showed inhibitory activities on xylene-induced ear edema, but only palmatine and columbamine exhibited significant inhibitory effects on acetic acid-induced writhing. In addition, palmatine and columbamine markedly inhibited in vitro production of nitric oxide and nuclear factor-κB activation in RAW264.7 macrophage cells in response to lipopolysaccharide or tumor necrosis factor α stimulation. These results provide justification for the utilization of Radix Tinosporae in Chinese folk medicine for the treatment of inflammatory diseases.
Three new sesquiterpene lactones from Inula britannica
Xufeng Zhang,Jing-Ling Du,Jie Ren,Feng-Mei Ye,Yang-Guo Xie,Xiangrong Cheng,Shi Kai Yan,Huizi Jin 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
One new 1,10-secoeudesmanolide (1), twoeudesmanolides (2 and 3), together with nine knowncompounds (4–12) were isolated from the aerial parts ofInula britannica. The structures of the new compoundswere elucidated by detailed spectroscopic analysis,including HRESIMS and 2D-NMR spectroscopic method. In addition, compounds 1–4 were tested for their inhibitoryeffects against LPS-induced NO production in RAW264.7macrophages.