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RISS 인기검색어
- 검색키워드
- 저자 : Hu Jinfang (검색결과 3 건)
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High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells
( Jinfang Hu ),( Zhiguo Zhang ),( Lei Zhao ),( Li Li ),( Wei Zuo ),( Lei Han ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.2
RAD51 recombinase plays a critical role in homologous recombination and DNA damage repair. Here we showed that expression of RAD51 is frequently upregulated in lung cancer tumors compared with normal tissues and is associated with poor survival (hazard ratio (HR) = 2, P = 0.0009). Systematic investigation of lung cancer cell lines revealed higher expression of RAD51 in KRAS mutant (MT) cells compared to wildtype (WT) cells. We further showed that MT KRAS, but not WT KRAS, played a critical role in RAD51 overexpression via MYC. Moreover, our results revealed that KRAS MT cells are highly dependent on RAD51 for survival and depletion of RAD51 resulted in enhanced DNA double strand breaks, defective colony formation and cell death. Together, our results suggest that mutant KRAS promotes RAD51 expression to enhance DNA damage repair and lung cancer cell survival, suggesting that RAD51 may be an effective therapeutic target to overcome chemo/radioresistance in KRAS mutant cancers. [BMB Reports 2019; 52(2): 151-156]
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Anti-rollover of the counterbalanced forklift truck based on model predictive control
Guang Xia,Jiacheng Li,Xiwen Tang,Yang Zhang,Jinfang Hu 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.5
To reduce the probability of a rollover accident of a forklift during high-speed steering, a hydraulic support cylinder is designed as an actuator to provide lateral support for the forklift. Aiming at the problem of judging the safety domain in the process of forklift driving, this paper proposes a strategy for dividing the forklift’s driving state on the basis of the zero moment point. The relationship between the zero moment point’s lateral component and the forklift’s support plane is used as the basis for division. The forklift rollover process is divided into a safe stage, a controllable danger stage, and a critical rollover stage. In the safe stage, the cylinder does not provide support force, and in the controllable danger stage, the cylinder support force is adjusted on the basis of the model predictive control algorithm to adjust the forklift. The cylinder can be controlled to provide maximum support for the body during the critical rollover phase. This method takes the three-degrees-of-freedom forklift anti-rollover model as the control object and serves as the basis for the calculation of the zero moment point. The anti-rollover controller is built in MATLAB/Simulink to simulate the European standard operating conditions and to verify the actual vehicle test. Results show that the predictive control of the forklift anti-rollover model based on the zero moment point can effectively improve the body attitude of the forklift during high-speed steering and prevent the forklift from rolling over.
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Anti-Rollover Control Based on Stable Zone Partition of Counterbalanced Forklift Trucks
Xia Guang,Xia Yan,Tang Xiwen,Zhao Linfeng,Hu Jinfang 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.6
To improve the anti-rollover capacity of a counterbalanced forklift, a two-stage rollover dynamic model is established on the basis of the forklift structure. Stable zones are divided according to the two-stage lateral load transfer rate: stable region, relatively stable region, dangerous zone and abnormal dangerous zone. An anti-rollover layered control strategy based on stable zone partition is proposed, and different anti-rollover control actuators are selected: dynamic balance weight, anti-rollover cylinder and steering cylinder. Anti-rollover controllers consist of the upper stable region identification controller, the middle-level controller based on model predictive control (MPC) and the lower layer executive controller. The upper stable region identification controller performs stable zone recognition based on the two-stage lateral load transfer rate. The middlelevel MPC controller calculates the required control torque with the body’s lateral angle and yaw rate as the control objectives. The lower layer executive controller controls the balance weight, anti-rollover cylinder and the steering cylinder according to the improved chain incremental allocation method to meet the target control torque. Simulation and real vehicle tests based on MATLAB/Simulink show that the anti-rollover control based on stable zone partition can greatly reduce the risk of forklift rollover and improve the forklift safety.
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