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RISS 인기검색어
- 검색키워드
- 저자 : Howaida I. Abd-Alla (검색결과 4 건)
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Howaida I. Abd-Alla,Nagat S. Abu-Gabal,Amal Z. Hassan,Mounir M. El-Safty,Nagwa M. M. Shalaby 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8
Evaluation of the antiviral activities of flowers, flower-peduncles, leaves, and roots of Aloe hijazensis against haemagglutinating viruses of avian paramyxovirus type-1 (APMV-1), avian influenza virus type A (AI-H5N1), Newcastle disease virus (NDV), and egg-drop syndrome virus (EDSV) in specific pathogen free (SPF) chicken embryos were carried out. Extract of the flowers and leaves showed relatively higher activity than the extracts of other plant parts. Thirteen compounds were isolated from both the flowers and flower-peduncles of A. hijazensis. The isolated compounds were classified into: five anthraquinones; ziganein, ziganein-5-methyl ether, aloesaponarin I, chrysophanol, aloe-emodin, one dihydroisocoumarin; feralolide, four flavonoids; homoplantaginin, isoorientin, luteolin 7-glucuronopyranoside, isovitexin, one phenolic acid; p-coumaric acid, the anthrone; barbaloin together with aloenin. Eleven compounds were attributed to the flowers and seven to the flower-peduncles. Homoplantaginin and luteolin 7-glucuronopyranoside are reported here for the first time from Aloe spp. To the best of our knowledge, this is the first report on the chemical composition and biological activity of those plant parts.
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Howaida I. Abd-Alla,Dalila Souguir,Mohamed O. Radwan 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.11
Sophora is deemed as one of the most remarkablegenera of Fabaceae, and the third largest family offl owering plants. The genus Sophora comprises approximately52 species, 19 varieties, and 7 forms that are widelydistributed in Asia and mildly in Africa. Sophora speciesare recognized to be substantial sources of broad spectrumbiopertinent secondary metabolites namely fl avonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins,benzofuran derivatives, sterols, saponins (mainly triterpeneglycosides), oligostilbenes, and mainly alkaloids. Meanwhile,extracts and isolated compounds from Sophora havebeen identifi ed to possess several health-promising eff ectsincluding anti-infl ammatory, anti-arthritic, antiplatelets,antipyretic, anticancer, antiviral, antimicrobial, antioxidant,anti-osteoporosis, anti-ulcerative colitis, antidiabetic, antiobesity,antidiarrheal, and insecticidal activities. Herein,the present review aims to provide comprehensive detailsabout the phytochemicals and biological eff ects of Sophoraspecies. The review spotlighted on the promising phytonutrientsextracted from Sophora and their plethora of bioactivities. The review also clarifi es the remaining gapsand thus qualifi es and supplies a platform for further investigationsof these compounds.
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Howaida I. Abd-Alla,Nagwa M. M. Shalaby,Manal A. Hamed,Nagy Saba El-Rigal,Samira N. Al-Ghamdi,Jalloul Bouajila 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.1
Three sesquiterpene lactones [two germacranolides (micranthin and sintenin) and one guaianolide (4b,10adihydroxy- 5b,7b,8bH-guaia-1,11(13)dien-12,8a-olide)] and four derivatives of 3-methoxy flavones (santin, quercetagetin- 3,6,30-trimethyl ether, quercetagetin-3,6-dimethyl ether, and 5,7 dihydroxy 3,30,40-trimethoxy flavone) were isolated from the ethyl acetate extract (EAE) of the aerial parts of Achillea biebersteinii Afan. (Asteraceae). Evaluation of protective and therapeutic effects of EAE against ethanol-induced gastric ulcer in rats was carried. Antiulcer activity evaluation was done through measuring ulcer indices, stomach acidity, gastric volume and lesion counts. Oxidative stress markers; malondialdehyde, glutathione and superoxide dismutase were also estimated. The work was extended to determine the histopathological assessment of the stomach. Gastric ulcer exhibited a significant elevation of the ulcer index and oxidative stress markers. The extract attenuated these increments and recorded protective and therapeutic effects against gastric ulcer. Hyperglycaemia increases the mucosal susceptibility to ulcerogenic stimuli and predisposes gastric ulceration. In vitro a-amylase inhibitory assay was applied to evaluate the post prandial antihyperglycaemia activity. The result showing that the EAE has the ability to reduce starch-induced postprandial glycaemic excursions by virtue of potent intestinal a-amylase inhibitory activity. These findings demonstrated the remarkable potential of A. biebersteinii as valuable source of antiulcer agent with post prandial hyperglycaemia lowering effect.
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Emad M. Kassem,Howaida I. Abd-Alla,Eslam R. El-Sawy,Adel H. Mandour,Dina Abdel-Mogeed,Mounir M. El-Safty 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.6
A series of fused pyranopyrazole and pyranoimidazole, namely 5-(3,6-diamino-4-aryl-5-carbonitrile-pyrano(2,3-c)pyrazol-2-yl)sulphonyl-8-hydroxyquinolines (5a-e), 5-(6-amino-4-aryl-5-carbonitrile-pyrano(2,3-c)pyrazol-3-yl)sulphonamido-8-hydroxyquinolines (6a-e), 5-(2-thioxo-4-aryl-5-carbonitrile-6-amino-pyrano(2,3-d)imidazol-2-yl)sulphonyl-8-hydroxyquinolines (10a-e), and 5-(2-oxo-4-aryl-5-carbonitrile-6-amino-pyrano(2,3-d)imidazol-2-yl) sulphonyl-8-hydroxyquinolines (11a-e), have been prepared via condensation of some arylidine malononitriles with 5-sulphonamido-8-hydroxyquinoline derivatives 3, 4, 8 and 9. All the synthesized compounds were screened for their antimicrobial activities, and most of the tested compounds showed potent inhibition growth activity towards Escherichia coli, Pseudomonas aeruginosa (Gramnegative bacteria). Furthermore, six selected compounds were tested for their antiviral activity against avian paramyxovirus type1 (APMV-1) and laryngotracheitis virus (LTV), and the results showed that a concentration range of 3-4 μg per mL of compounds 2, 3, and 4 showed marked viral inhibitory activity for APMV-1 of 5000 tissue culture infected dose fifty (TCID50) and LTV of 500 TCID50 in Vero cell cultures based on their cytopathic effect. Chicken embryo experiments show that compounds 2, 3, and 4 possess high antiviral activity in vitro with an inhibitory concentration fifty (IC50) range of 3-4 μg per egg against avian APMV-1 and LTV and their toxic concentration fifty (CC50) of 200-300 μg per egg.
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