Antinociceptive and sedative effects of the bark of Cerbera odollam Gaertn.

Ahmed, Firoj,Hossain, M Hemayet,Rahman, Ahmed Ayedur,Shahid, Israt Zahan Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.4

The crude methanolic extract of the bark of Cerbera odollam Gaertn. was evaluated for its possible antinociceptive and neuropharmacological activities in animal models. At the dose of 250 and 500 mg/kg body weight, the extract showed a significant antinociceptive effect in acetic acid induced writhing in mice comparable to that produced by aspirin, used as standard drug (P<0.001). The extract significantly reduced the time of onset of sleep (P<0.01) and potentiated the pentobarbital induced sleeping time in mice at the dose of 400 mg/kg of body weight significantly (P<0.001). It also decreased the open field score in open field test significantly at the dose of 400 mg/kg of body weight (P < 0.05). The obtained results tend to suggest the probable antinociceptive and neuropharmacological activities of the crude extract.

Analysis of sedimentary facies and depositional environments of the Permian Gondwana sequence in borehole GDH-45, Khalaspir Basin, Bangladesh

H.M. Zakir Hossain,M. Sultan-Ul-Islam,Syed Samsuddin Ahmed,Ismail Hossain 한국지질과학협의회 2002 Geosciences Journal Vol.6 No.3

Lithofacies analysis of the Permian Gondwana sequencein borehole GDH-45 of the Khalaspir Basin was performed with aview to deduce the nature of depositional environments. On thebasis of dominant lithofacies association, the sequence is dividedinto six lithostratigraphic units (units A to F). Five lithofacies (con-glomerate, sandstone, siltstone, mudstone/shale and coal) are iden-tified within these units. Several sub-lithofacies, such as masive,crudely stratified, cross-stratified, ripple and parallel laminatedsandstones are also identified within these lithofacies. The sequenceforms a fining-upward trend with a rare coarsening-upward unit.The generalised Gondwana sequence is characterised mainly bychannel lags, pebbly massive to crudely cross-stratified sandstone,trough and planar cross-stratified sandstone, ripple laminatedsandstone/siltstone, massive to parallel laminated siltstone, mud-stone/shale and coal in ascending order. The facies associationsrepresent several repeated fining-upward units and cycles, indi-cating various sub-environments (channel, floodplain, flood basin/backswamp) in fluvial regime. The conglomerates might have bendeposited as debris flow or channel lag deposits. The sandstoneswere deposited mainly as multistoried channel and lateral bars inmoderately braided and sinuous streams. The siltstone and mud-stone lithofacies indicate bar top, natural levee or floodplain toflood basin environments. The coal lithofacies suggests depositionin low-lying, short to long persistent, moderately to well drainedand sparse to densely vegetated backswamps in fluvial channel-flood-plain complex. The overall succession of the Gondwana borehole sed-iments sugests that the depositional basin became, with time, gentlerin slope gradient, resulting in a more sinuous stream setting.

Association Assessment among Risk Factors and Breast Cancer in a Low Income Country: Bangladesh

Ahmed, Kawsar,Asaduzzaman, Sayed,Bashar, Mamun Ibn,Hossain, Goljar,Bhuiyan, Touhid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Background: In the low incoming country Bangladesh, breast cancer is second most common neoplasm and is increasing at an alarming rate among females. Lack of awareness and illiteracy are contributory factors for late presentation and therefore mortality. Purpose: To examine associations of different factors with breast cancer mortality and to raise awareness among the women of society in Bangladesh. Materials and Methods: This descriptive case-control study was conducted on 160 participants from April 2011 till July 2014. Through a valid questionnaire covering personal and family history, data were collected by face to face interview. For analyzing correlations among factors with breast cancer data, binary logistic regression, Pearson's ${\chi}^2$-value, odd ratios and p-value tests were conducted with SPSS version 20. Results: The mean age of the patients was 43.0 ($SD={\pm}11.12$). In ascending order the leading significant factors were hormone therapy (p<0.0000, OR=4.897), abortion (p<0.0001, OR=3.452), early start menarche (p<0.0002, OR=3.500), family history (p<0.0022, OR=3.235), and late menopause (p<0.0093, OR=3.674) with both ${\chi}^2$ test and logistic regression analyses. Non-significant factors were cancer experience, fatty food habits, marital status and taking alcohol. Conclusions: Regarding the investigation of this study, significant and insignificant factor's correlation visualization with breast cancer will be helpful to increase awareness among Bangladeshi women as well as all over the world.

Effects of Resveratrol and Essential Oils on Growth Performance, Immunity, Digestibility and Fecal Microbial Shedding in Challenged Piglets

Ahmed, S.T.,Hossain, M.E.,Kim, G.M.,Hwang, J.A.,Ji, H.,Yang, C.J. Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.5

A study was conducted to evaluate the effects of resveratrol and essential oils from medicinal plants on the growth performance, immunity, digestibility, and fecal microbial shedding of weaned piglets. A total of 48 weaned piglets (8 kg initial weight, 28-d-old) were randomly allotted to four dietary treatments with 3 replications of 4 piglets each. The dietary treatments were NC (negative control; basal diet), PC (positive control; basal diet+0.002% apramycin), T1 (basal diet+0.2% resveratrol), and T2 (basal diet+0.0125% essential oil blend). All piglets were orally challenged with 5 ml culture fluid containing $2.3{\times}10^8$ cfu/ml of Escherichia coli KCTC 2571 and $5.9{\times}10^8$ cfu/ml Salmonella enterica serover Typhimurium. The PC group (p<0.05) showed the highest average daily gain (ADG) and average daily feed intake (ADFI) throughout the experimental period, although feed conversion ratio (FCR) was improved in the T1 group (p>0.05). Serum IgG level was increased in the T1 group, whereas TNF-${\alpha}$ levels was reduced in the supplemented groups compared to control (p<0.05). The PC diet improved the dry matter (DM) digestibility, whereas PC and T2 diets improved nitrogen (N) digestibility compared to NC and T1 diets (p<0.05). Fecal Salmonella and E. coli counts were reduced in all treatment groups compared to control (p<0.05). Fecal Lactobacillus spp. count was increased in the T2 group compared to others (p<0.05). Dietary treatments had no significant effect on fecal Bacillus spp. count throughout the entire experimental period. Based on these results, resveratrol showed strong potential as antibiotic alternatives for reversing the adverse effects of weaning stress on growth performance, immunity and microbial environment in E. coli and Salmonella-challenged piglets.

Syzygium cumini (L.) skeels seed extract ameliorates in vitro and in vivo oxidative potentials of the brain cerebral cortex of alcohol-treated rats - Syzygium cumini (L.) skeels seed extract inhibits oxidative potentials of brain

Hossain, Shahdat,Rahaman, Asiqur,Nahar, Taslima,Basunia, Mafroz Ahmed,Mowsumi, Ferdousi Rahman,Uddin, Borhan,Shahriar, Masum,Mahmud, Ishtiaq 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.1

We investigated the effect of Syzygium cumini (L.) Skeels seed extract on the oxidative stress of brain cortical tissues of alcohol-treated rats. The in vitro antioxidative effect of methnolic S. cumini seed extract was initially compared with those of the buytylated hydroxyl toluene (BHT) and Vitamin C, by determining their DPPH-free radical scavenging activity. The S. cumini seed extract exhibited stronger free radical scavenging activity than those of the BHT and Vitamin C. Cortex homogenates were then directly incubated with 15% ethanol and/or Fenton's reagent ($H_2O_2+Fe_2SO_4$) to induce in vitro oxidative stress in the absence or presence of S. cumini seed extract. The S. cumini seed extract significantly reduced the levels of lipid peroxide (LPO) in the cortical homogenates. Twenty four rats were then divided into four groups: Control, S. cumini seed extract (SE)-administered, 15% ethanol-fed (EtOH) and EtOH+SE rats. The oral administration of the extract (400 mg/kg BW.day) for 8 weeks significantly (P<0.05) decreased the levels of LPO in the cortex of the EtOH+SE rats, suggesting that S. cumini seed not only scavenged the DPPH-free radicals and obstructed the ethanol/Fenton's reagents-induced in vitro oxidative stress of the cortical tissues but also reduced their in vivo formation. These results suggest that S. cumini seed could be used as a potential antioxidant therapy for alcoholics.

Immune priming and a lipocalin in a lepidopteran insect, Spodoptera exigua

Shabbir Ahmed,Md Tafim Hossain Hrithik,Yonggyun Kim 한국응용곤충학회 2022 한국응용곤충학회 학술대회논문집 Vol.2022 No.04

Plastic pollution in Bangladesh: A review on current status emphasizing the impacts on environment and public health

Shafiul Hossain,Md Anisur Rahman,Myisha Ahmed Chowdhury,Sajib Kumar Mohonta 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.6

Invention of the plastics has largely been considered as a boon for the modern life due to their light weight, high strength, and versatile application while being cheaper than other alternative materials. However, with the low biodegradability, over consumption, and widespread mismanagement, plastics have now become ubiquitous in all the environmental compartments and are held responsible for causing enormous pollution to air, soil, and water bodies. Bangladesh is no different from this global scenario, though there has been a little effort to assess the amount of plastic waste and its consequence which is necessary to encounter this mounting threat effectively. Taking this into consideration, current study investigates the impacts of plastic pollution including its most threatening form microplastics on environment and human health in Bangladesh. The study is based on critical review of existing literatures from the global perspective. It has been found that a major percentage of the used plastic is mismanaged in Bangladesh, posing a great threat to the environment and human health. This article also put forward some recommendations to tackle this pervasive problem alongside the measures already taken by the government. Overall, this work is aimed at creating an urge among the researchers to study the plastic pollution in Bangladesh comprehensively and raising a concern among the appropriate authorities to develop policies and impose necessary actions against plastic pollution before it is too late.

Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells

Kawser Hossain, Mohammed,Abdal Dayem, Ahmed,Han, Jihae,Kumar Saha, Subbroto,Yang, Gwang-Mo,Choi, Hye Yeon,Cho, Ssang-Goo MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.2

<P>Diabetes mellitus (DM) is a widespread metabolic disease with a progressive incidence of morbidity and mortality worldwide. Despite extensive research, treatment options for diabetic patients remains limited. Although significant challenges remain, induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any cell type, including insulin-secreting pancreatic β cells, highlighting its potential as a treatment option for DM. Several iPSC lines have recently been derived from both diabetic and healthy donors. Using different reprogramming techniques, iPSCs were differentiated into insulin-secreting pancreatic βcells. Furthermore, diabetes patient-derived iPSCs (DiPSCs) are increasingly being used as a platform to perform cell-based drug screening in order to develop DiPSC-based cell therapies against DM. Toxicity and teratogenicity assays based on iPSC-derived cells can also provide additional information on safety before advancing drugs to clinical trials. In this review, we summarize recent advances in the development of techniques for differentiation of iPSCs or DiPSCs into insulin-secreting pancreatic β cells, their applications in drug screening, and their role in complementing and replacing animal testing in clinical use. Advances in iPSC technologies will provide new knowledge needed to develop patient-specific iPSC-based diabetic therapies.</P>

Increasing Nitrogen Use Efficiency in Rice Through Nitrogen and Water Management

Mahmud Hossain Sumon,Rifat Mahbuba,Maruf Ahmed,Shuberna Akter,M Jahiruddin 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Plastic pollution in Bangladesh: A review on current status emphasizing the impacts on environment and public health

Shafiul Hossain,Md Anisur Rahman,Myisha Ahmed Chowdhury,Sajib Kumar Mohonta 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.6

Invention of the plastics has largely been considered as a boon for the modern life due to their light weight, high strength, and versatile application while being cheaper than other alternative materials. However, with the low biodegradability, over consumption, and widespread mismanagement, plastics have now become ubiquitous in all the environmental compartments and are held responsible for causing enormous pollution to air, soil, and water bodies. Bangladesh is no different from this global scenario, though there has been a little effort to assess the amount of plastic waste and its consequence which is necessary to encounter this mounting threat effectively. Taking this into consideration, current study investigates the impacts of plastic pollution including its most threatening formmicroplastics on environment and human health in Bangladesh. The study is based on critical review of existing literatures from the global perspective. It has been found that a major percentage of the used plastic is mismanaged in Bangladesh, posing a great threat to the environment and human health. This article also put forward some recommendations to tackle this pervasive problem alongside the measures already taken by the government. Overall, this work is aimed at creating an urge among the researchers to study the plastic pollution in Bangladesh comprehensively and raising a concern among the appropriate authorities to develop policies and impose necessary actions against plastic pollution before it is too late.