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- 저자 : Hilma Putri Lubis (검색결과 1 건)
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Binarwan Halim,Hilma Putri Lubis 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.2
ObjectiveThe objective of this study was to evaluate the effectiveness of dual trigger, which is a combination of gonadotropinreleasingagonist (GnRH-a) and recombinant human chorionic gonadotropin (hCG) in the final oocyte maturation, inthe outcome of intrauterine insemination (IUI). MethodsThis retrospective observational study was conducted from January 2016 to October 2018 and involved 639 IUI cyclesat the Halim Fertility Center, Indonesia. Controlled ovarian stimulation was performed during IUI cycles. The ovulationtriggers were divided into two groups: group I received a combination of GnRH-a and recombinant hCG as a dualtrigger, and group II received only recombinant hCG as a single trigger. The baseline characteristics, cycle parameters,and IUI outcomes of both groups were compared. ResultsOur study included a total of 639 IUI cycles, 334 were in the dual trigger group and 305 in the single trigger group. The clinical pregnancy rates were significantly higher in the dual trigger group than in the single trigger group(P<0.001). Based on the multivariate analysis, the dual trigger increased the clinical pregnancy rate by 2.524 timesthan that by the single trigger. ConclusionOur data showed that the dual trigger combination of GnRH-a and recombinant hCG significantly improves theoutcome of intrauterine insemination.
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