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        Effectiveness of self-training using the mobile-based virtual reality program in patients with social anxiety disorder

        Kim, Hesun Erin,Hong, Yeon-Ju,Kim, Min-Kyeong,Jung, Young Hoon,Kyeong, Sunghyon,Kim, Jae-Jin Pergamon 2017 Computers in human behavior Vol.73 No.-

        <P><B>Abstract</B></P> <P>Social anxiety is one of the common mental problems with relatively low treatment-seeking rate. Virtual reality exposure therapy is a promising treatment option for social anxiety disorder (SAD). Our objective was to investigate the efficacy of self-training using the newly developed mobile-based virtual reality program for the cost-effective treatment of SAD. Twenty-two patients with SAD and 30 sex- and age-matched normal controls engaged in the program, which consisted of eight self-training sessions during two weeks. Liebowitz Social Anxiety Scale (LSAS) was assessed before and after the training. Additionally, the embedded in-app performance variables were analyzed for objective performance improvements. Although the LSAS scores decreased after the training in both groups, patients showed greater degree of decrease at the marginal significance level than controls (<I>p</I> = 0.053). Overall, there were significant improvements in the total speech length (<I>p</I> < 0.001), voiced-time ratio (<I>p</I> < 0.001), and subjective self-ratings on the performance measured within the program for subjective nervousness (<I>p</I> < 0.001) and for the subjective confidence in content (<I>p</I> = 0.039). The findings provide compelling evidence that the self-training could be beneficial for reducing anxiety and improving skills. The mobile-based virtual reality program for the treatment of SAD may be the first mobile application treatment option that could be operated by the patient alone, at home.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mobile-based virtual reality self-training for social anxiety was developed. </LI> <LI> The mobile program attenuated social anxiety. </LI> <LI> Through the program, participants were able to improve performance skills. </LI> </UL> </P>

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        The Relationship between Delirium and Statin Use According to Disease Severity in Patients in the Intensive Care Unit

        Jun Yong An(Jun Yong An),Jin Young Park(Jin Young Park),Jaehwa Cho(Jaehwa Cho),Hesun Erin Kim(Hesun Erin Kim),Jaesub Park(Jaesub Park),Jooyoung Oh(Jooyoung Oh) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

        Objective: The aim of this study was to investigate the association between the use of statins and the occurrence of delirium in a large cohort of patients in the intensive care unit (ICU), considering disease severity and statin properties. Methods: We obtained clinical and demographical information from 3,604 patients admitted to the ICU from January 2013 to April 2020. This included information on daily statin use and delirium state, as assessed by the Confusion Assessment Method for ICU. We used inverse probability of treatment weighting and categorized the patients into four groups based on the Acute Physiology and Chronic Health Evaluation II score (group 1: 0−10 - mild; group 2: 11−20 - mild to moderate; group 3: 21−30 - moderate to severe; group 4: > 30 - severe). We analyzed the association between the use of statin and the occurrence of delirium in each group, while taking into account the properties of statins. Results: Comparisons between statin and non-statin patient groups revealed that only in group 2, patients who were administered statin showed significantly higher occurrence of delirium (p = 0.004, odds ratio [OR] = 1.58) compared to the patients who did not receive statin. Regardless of whether statins were lipophilic (p = 0.036, OR = 1.47) or hydrophilic (p = 0.032, OR = 1.84), the occurrence of delirium was higher only in patients from group 2. Conclusion: The use of statins may be associated with the increases in the risk of delirium occurrence in patients with mild to moderate disease severity, irrespective of statin properties.

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